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24 December 2018 | Story Leonie Bolleurs | Photo Anja Aucamp
Research possibilities of zebrafish exposed
Leading global genetics laboratories are replacing research on human and animal populations with zebrafish, says Prof Paul Grobler, Head of the UFS Department of Genetics.

The UFS Department of Genetics is on par with current research trends in terms of their zebrafish project. About a year has passed since they seriously started focusing on the potential of this tiny four-centimetre-long fish, and the possibilities are hugely exciting.

Looks are deceiving

Leading global genetics laboratories are replacing research on human and animal populations with zebrafish due to several fascinating reasons, of which the most profound is probably that the zebrafish share large portions of its genome with mammals. For genetics researchers this may make a lot of sense, but most people battle to see any resemblance between a six-foot-tall rugby player or 600 kg buffalo and a small, nearly transparent fish. It is in the detail, the researchers say.

Fast, effective, and visible

“The complete genome sequence of the zebrafish is known, and as much as 84% of genes known to be associated with human disease have zebrafish counterparts,” explains Head of Department, Prof Paul Grobler. Another advantage is the fast breeding rate and short generation time, and the fact that some research is ethically more justifiable when done on fish larvae rather than on adult mammals. The fact that zebrafish embryos are virtually transparent, also allow researchers to examine the development of internal structures without effort. Every blood vessel in a living zebrafish embryo is visible under a low-power microscope.

Multidisciplinary

Zebrafish provide research potential for many different study fields besides that of Prof Grobler and his team, Sue Rica Schneider and Dr Willem Coetzer. In the near future, they aim to have undergraduate students use zebrafish as a research model to develop a real sense of research and laboratory work. The Department of Chemistry are also initiating research on zebrafish housed in the Department of Genetics.

News Archive

Prof Habib addresses inequality at public lecture
2014-08-06

 
One of South Africa’s leading political commentators, Prof Adam Habib, gave a public lecture and launched his latest book on the Bloemfontein Campus on Wednesday 30 July 2014. The event was hosted by the Department of Philosophy in association with Wits University Press and The Southern African Trust.

Prof Habib started his lecture by summarising his book, ‘South Africa’s Suspended Revolution: Hopes and Prospects’. “It is basically about: how did we get where we are today, and how do we get out of the mess we are in?” he said.

His book focuses on South Africa’s transition into democracy and the country’s prospects for inclusive development – which formed the basis of his talk. Prof Habib stressed the issue of inequality facing South Africa and discussed the different approaches to addressing the matter.

“The one approach is that it is simply something we have to live with,” he said. “People who believe this live in a bubble. For example, service delivery protests do not happen because of poverty – it happens because of inequality.”

Prof Habib cautioned against not taking the matter seriously. “Inequality went up consistently in South Africa over the last 20 years. This is however not solely a national challenge, but a global challenge. And South Africa is the frontline of the war on inequality.”

He proposed that the expectations of the rich, rather than the poor, should be addressed.
“We need to moderate expectations. But we can’t moderate the expectations of the poor, if not the rich. We can’t ask the poor to sacrifice what the rich won’t.

“South Africa is once again at a moment of reckoning, where we are forced to make hard choices – in order to make the right choices.”


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