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24 December 2018 | Story Leonie Bolleurs | Photo Anja Aucamp
Research possibilities of zebrafish exposed
Leading global genetics laboratories are replacing research on human and animal populations with zebrafish, says Prof Paul Grobler, Head of the UFS Department of Genetics.

The UFS Department of Genetics is on par with current research trends in terms of their zebrafish project. About a year has passed since they seriously started focusing on the potential of this tiny four-centimetre-long fish, and the possibilities are hugely exciting.

Looks are deceiving

Leading global genetics laboratories are replacing research on human and animal populations with zebrafish due to several fascinating reasons, of which the most profound is probably that the zebrafish share large portions of its genome with mammals. For genetics researchers this may make a lot of sense, but most people battle to see any resemblance between a six-foot-tall rugby player or 600 kg buffalo and a small, nearly transparent fish. It is in the detail, the researchers say.

Fast, effective, and visible

“The complete genome sequence of the zebrafish is known, and as much as 84% of genes known to be associated with human disease have zebrafish counterparts,” explains Head of Department, Prof Paul Grobler. Another advantage is the fast breeding rate and short generation time, and the fact that some research is ethically more justifiable when done on fish larvae rather than on adult mammals. The fact that zebrafish embryos are virtually transparent, also allow researchers to examine the development of internal structures without effort. Every blood vessel in a living zebrafish embryo is visible under a low-power microscope.

Multidisciplinary

Zebrafish provide research potential for many different study fields besides that of Prof Grobler and his team, Sue Rica Schneider and Dr Willem Coetzer. In the near future, they aim to have undergraduate students use zebrafish as a research model to develop a real sense of research and laboratory work. The Department of Chemistry are also initiating research on zebrafish housed in the Department of Genetics.

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Honouring Stanley Trapido – one of the most influential historians South Africa has produced
2014-08-14

 

Prof Charles van Onselen
Photo: Supplied

The International Studies Group and the History Department at the UFS hosted a seminar on Stanley Trapido by Prof Charles van Onselen on Monday 11 August 2014.

The seminar honoured the life and work of Trapido, one of the most important and influential historians South Africa has ever produced.

Trapido is probably best known for his work on the causes and consequences of the South African War of 1899–1902. It was to this broad time period that Prof Van Onselen spoke in his paper ‘The Political Economy of the South African Republic, 1881–1895’.

Prof Van Onselen’s lecture provided a major reinterpretation of the origins and causes of the Jameson Raid while emphasising that Paul Kruger’s ZAR was a state beset by crime and corruption. It was particularly fitting that Prof Van Onselen gave the inaugural seminar paper, since Trapido supervised his Oxford doctoral thesis.

The International Studies Group and the History Department were extremely honoured by Trapido’s widow, the Booker Prize nominated author Barbara, attending the seminar. They wish to thank her for donating her husband’s academic library to the UFS.

Following the Sharpeville massacre of 1960, the Trapido-couple emigrated to England. While there, Trapido began to shape what is now known as the ‘revisionist’ school of South African historiography. He argued the importance of analysing capital and class formation, which he maintained informed the racial ideologies that culminated in apartheid.

Prof Van Onselen’s inaugural seminar presentation will be followed later this term by papers from David Moore, Sabelo Ndlovu-Gatsheni and Giacomo Macola.

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