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24 December 2018 | Story Leonie Bolleurs | Photo Anja Aucamp
Research possibilities of zebrafish exposed
Leading global genetics laboratories are replacing research on human and animal populations with zebrafish, says Prof Paul Grobler, Head of the UFS Department of Genetics.

The UFS Department of Genetics is on par with current research trends in terms of their zebrafish project. About a year has passed since they seriously started focusing on the potential of this tiny four-centimetre-long fish, and the possibilities are hugely exciting.

Looks are deceiving

Leading global genetics laboratories are replacing research on human and animal populations with zebrafish due to several fascinating reasons, of which the most profound is probably that the zebrafish share large portions of its genome with mammals. For genetics researchers this may make a lot of sense, but most people battle to see any resemblance between a six-foot-tall rugby player or 600 kg buffalo and a small, nearly transparent fish. It is in the detail, the researchers say.

Fast, effective, and visible

“The complete genome sequence of the zebrafish is known, and as much as 84% of genes known to be associated with human disease have zebrafish counterparts,” explains Head of Department, Prof Paul Grobler. Another advantage is the fast breeding rate and short generation time, and the fact that some research is ethically more justifiable when done on fish larvae rather than on adult mammals. The fact that zebrafish embryos are virtually transparent, also allow researchers to examine the development of internal structures without effort. Every blood vessel in a living zebrafish embryo is visible under a low-power microscope.

Multidisciplinary

Zebrafish provide research potential for many different study fields besides that of Prof Grobler and his team, Sue Rica Schneider and Dr Willem Coetzer. In the near future, they aim to have undergraduate students use zebrafish as a research model to develop a real sense of research and laboratory work. The Department of Chemistry are also initiating research on zebrafish housed in the Department of Genetics.

News Archive

Short course in Applied Conservation Genetics developed at UFS
2014-08-22

 

Photo: en.wikipedia.org

During discussions with stakeholders in Kenya in 2013, a need was identified for training in conservation genetics with an African emphasis. In answer, Prof Paul Grobler from the Department of Genetics developed a short course in Applied Conservation Genetics.

Some of the phenomena studied in this field include:
• hybridisation between species such as blue wildebeest and black wildebeest,
• wildlife poaching and
• potential inbreeding in small game-farm populations.

From the onset, the course has been developed as an international venture. To this end, Dr Frank Zachos from the Natural History Museum in Vienna, Austria, committed himself to the project. Dr Jamie Roberts from the Department of Fish and Wildlife Conservation at Virginia Tech University in the USA also came on board. Both pledged their time and expertise to the course – without any financial gain.

Subsequently, our Department of Genetics presented this short course at the National Zoological Gardens (NZG) in Pretoria earlier this year. The team of presenters included Prof Grobler, Dr Zachos and Dr Roberts. They were joined by Dr Desire Dalton from the Research Division of the NZG, who added valuable practical experience to the presentations.

The course assumes a degree of prior knowledge of population and molecular genetics. A strong emphasis is placed on practical applications. The programme includes a strong component of statistics and hands-on training in the many approaches and software used in population genetics.

The group that attended the course included a contingent from the Namibian Ministry of Environment and Tourism, Dutch postgraduate students currently working at the University of Johannesburg and delegates from across South Africa.

This successful meeting followed an experimental first round of the course presented in Nairobi during 2013, attended by representatives from Kenya, Malawi, Nigeria, Mexico and Belgium.


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