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24 December 2018 | Story Leonie Bolleurs | Photo Anja Aucamp
Research possibilities of zebrafish exposed
Leading global genetics laboratories are replacing research on human and animal populations with zebrafish, says Prof Paul Grobler, Head of the UFS Department of Genetics.
The UFS Department of Genetics is on par with current research trends in terms of their zebrafish project. About a year has passed since they seriously started focusing on the potential of this tiny four-centimetre-long fish, and the possibilities are hugely exciting.

Looks are deceiving

Leading global genetics laboratories are replacing research on human and animal populations with zebrafish due to several fascinating reasons, of which the most profound is probably that the zebrafish share large portions of its genome with mammals. For genetics researchers this may make a lot of sense, but most people battle to see any resemblance between a six-foot-tall rugby player or 600 kg buffalo and a small, nearly transparent fish. It is in the detail, the researchers say.

Fast, effective, and visible

“The complete genome sequence of the zebrafish is known, and as much as 84% of genes known to be associated with human disease have zebrafish counterparts,” explains Head of Department, Prof Paul Grobler. Another advantage is the fast breeding rate and short generation time, and the fact that some research is ethically more justifiable when done on fish larvae rather than on adult mammals. The fact that zebrafish embryos are virtually transparent, also allow researchers to examine the development of internal structures without effort. Every blood vessel in a living zebrafish embryo is visible under a low-power microscope.

Multidisciplinary

Zebrafish provide research potential for many different study fields besides that of Prof Grobler and his team, Sue Rica Schneider and Dr Willem Coetzer. In the near future, they aim to have undergraduate students use zebrafish as a research model to develop a real sense of research and laboratory work. The Department of Chemistry are also initiating research on zebrafish housed in the Department of Genetics.

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News Archive

The challenges of local governance highlighted at the JN Boshoff Memorial lecture
2014-08-26

 

Mr Kopung Ralikontsane
Photo: Jerry Mokoroane

The annual JN Boshoff memorial lecture was hosted by the Faculty of Economics and Management Sciences in conjunction with the Department of Public Management on 21 August 2014. Mr Kopung Ralikontsane, Director-general of the Free State Provincial Government, presented the keynote address, ‘Challenges Facing Local Government in Service Delivery’.

In his opening remarks, Mr Ralikontsane gave the background of the South African municipal structures, the legal framework within which they operate and the challenges they are currently facing. He added that “local government is a sphere at the coalface of service delivery and if this sphere fails, South Africa would have failed to be a developmental state.”

He said the Free State provincial government has made great strides in developing local communities, with millions of rands invested in various development projects such as water and sanitation, electrification, roads and storm water structures, community facilities and solid waste disposal.

Local government is still faced with other challenges, though. He pointed out that public employees are subject to greater scrutiny and increased demands from citizens. As a result, they have to provide better services, but within stricter limits on resources. Conflict arises due to changing relationships between public servants and citizens, downsizing, restructuring and contracting out of government services and activities.

Despite the various structures implemented by local government, municipalities are serving an ever-growing population in an economic decline. Regulations have been put into place to devise credible Integrated Development Plans (IDPs) to improve municipal infrastructure, build competent management teams and strong operations and increase technical capacity for effective delivery of services.

Mr Ralikontsane invited students to join local government in crafting innovative solutions. “We know the problem, but we need to encourage you to join forces with your local government and tackle them.”

Mr Kopung Ralikontsane has served in local government for two decades and also serves as Head of Administration of the Free State Government and as Cabinet Secretary.


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