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24 December 2018 | Story Leonie Bolleurs | Photo Anja Aucamp
Research possibilities of zebrafish exposed
Leading global genetics laboratories are replacing research on human and animal populations with zebrafish, says Prof Paul Grobler, Head of the UFS Department of Genetics.

The UFS Department of Genetics is on par with current research trends in terms of their zebrafish project. About a year has passed since they seriously started focusing on the potential of this tiny four-centimetre-long fish, and the possibilities are hugely exciting.

Looks are deceiving

Leading global genetics laboratories are replacing research on human and animal populations with zebrafish due to several fascinating reasons, of which the most profound is probably that the zebrafish share large portions of its genome with mammals. For genetics researchers this may make a lot of sense, but most people battle to see any resemblance between a six-foot-tall rugby player or 600 kg buffalo and a small, nearly transparent fish. It is in the detail, the researchers say.

Fast, effective, and visible

“The complete genome sequence of the zebrafish is known, and as much as 84% of genes known to be associated with human disease have zebrafish counterparts,” explains Head of Department, Prof Paul Grobler. Another advantage is the fast breeding rate and short generation time, and the fact that some research is ethically more justifiable when done on fish larvae rather than on adult mammals. The fact that zebrafish embryos are virtually transparent, also allow researchers to examine the development of internal structures without effort. Every blood vessel in a living zebrafish embryo is visible under a low-power microscope.

Multidisciplinary

Zebrafish provide research potential for many different study fields besides that of Prof Grobler and his team, Sue Rica Schneider and Dr Willem Coetzer. In the near future, they aim to have undergraduate students use zebrafish as a research model to develop a real sense of research and laboratory work. The Department of Chemistry are also initiating research on zebrafish housed in the Department of Genetics.

News Archive

Weak states and armed movements – researching the underlying links
2014-08-28

 

Prof Theo Neethling is conducting research on armed movements in the DRC.
Photo: en.wikipedia.org

Prof Theo Neethling from the Department of Political Studies and Governance is currently conducting research on armed movements in the Democratic Republic of the Congo (DRC).

“My research is premised on the scholarly insight and argument that in weak states, such as the DRC, armed movements and militias are filling power vacuums that are the result of the inability and lack of military capacity to fight these movements effectively,” Prof Neethling says.

“In this context, the DRC is severely affected by sub-state terrorism,” he continues.

“This is a phenomenon that is intimately linked to the failure to effect sustained development and to consolidate accountable and effective governance in especially the eastern provinces of the country.”

Earlier this year, Prof Neethling presented conference papers on this topic at two international conferences: the Conference of the New York State Political Science Association, as well as the World International Studies Conference hosted in Frankfurt, Germany.

In 2013, Prof Neethling co-edited the book, ‘Post-Conflict Reconstruction and Development in Africa: Concepts, Policy, Role-players and Practice’. He completed this work in collaboration with Prof Heidi Hudson from the UFS Centre for Africa Studies.

“The book revolves around the concept of ‘post-conflict’ and the blurring of military and civilian roles, analysing the multiple roles of the United Nations in the DRC and Sierra Leone, as well as the African Union Mission in Burundi,” Prof Neethling says.

“It also explores South Africa’s foreign policy imperatives in relation to multinational peace missions in conflict-stricken African states, involving military as well as civilian role-players.” 
 
 
 
 
 

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