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24 December 2018 | Story Leonie Bolleurs | Photo Anja Aucamp
Research possibilities of zebrafish exposed
Leading global genetics laboratories are replacing research on human and animal populations with zebrafish, says Prof Paul Grobler, Head of the UFS Department of Genetics.

The UFS Department of Genetics is on par with current research trends in terms of their zebrafish project. About a year has passed since they seriously started focusing on the potential of this tiny four-centimetre-long fish, and the possibilities are hugely exciting.

Looks are deceiving

Leading global genetics laboratories are replacing research on human and animal populations with zebrafish due to several fascinating reasons, of which the most profound is probably that the zebrafish share large portions of its genome with mammals. For genetics researchers this may make a lot of sense, but most people battle to see any resemblance between a six-foot-tall rugby player or 600 kg buffalo and a small, nearly transparent fish. It is in the detail, the researchers say.

Fast, effective, and visible

“The complete genome sequence of the zebrafish is known, and as much as 84% of genes known to be associated with human disease have zebrafish counterparts,” explains Head of Department, Prof Paul Grobler. Another advantage is the fast breeding rate and short generation time, and the fact that some research is ethically more justifiable when done on fish larvae rather than on adult mammals. The fact that zebrafish embryos are virtually transparent, also allow researchers to examine the development of internal structures without effort. Every blood vessel in a living zebrafish embryo is visible under a low-power microscope.

Multidisciplinary

Zebrafish provide research potential for many different study fields besides that of Prof Grobler and his team, Sue Rica Schneider and Dr Willem Coetzer. In the near future, they aim to have undergraduate students use zebrafish as a research model to develop a real sense of research and laboratory work. The Department of Chemistry are also initiating research on zebrafish housed in the Department of Genetics.

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"Studies indicate disability, poverty and inaccessibility to healthcare are intricately linked " - expert opinion by Dr Magteld Smith
2014-12-03

Dr Magteld Smith

Programmes worldwide attempt to improve the lives of people with disabilities, but recent studies indicated that disability and poverty, as well as disability and the inaccessibility of health care, continues to go hand in hand.

In South Africa, and even in developed countries, research shows that people with disabilities achieve lower levels of education with higher unemployment rates, live in extreme poverty and have low living standards.

“To have a disability can therefore become a huge financial burden on either the disabled person, the family or caregivers,” says Dr Magteld Smith from the Department of Otorhinolaryngology.

She devotes her research to the medical-social model of the global organisation, the International Classification of Functioning, Disabilities and Health, focusing on all areas of deafness.

Furthermore, Dr Smith says it is more difficult or more expensive for people with disabilities to obtain insurance, because of the risks associated with disability.

Dr Smith also emphasises the inaccessibility and even unavailability of medical services or health care for people with disabilities.

“Services such as psychiatry or social services are often not accessible. When such services are available, it is not affordable for most people with disabilities.”

Dr Smith uses the example of a person who was born deaf:

“Doctors have limited knowledge of the different types of hearing impairments or how to read and interpret an audiogram. Very little understanding also exists for the impact of deafness on the person’s daily life.”

Dr Smith, who is deaf herself, describes the emotional state of mind of people with disabilities as a daily process of adjustment and self-evaluation.

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