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24 December 2018 | Story Leonie Bolleurs | Photo Anja Aucamp
Research possibilities of zebrafish exposed
Leading global genetics laboratories are replacing research on human and animal populations with zebrafish, says Prof Paul Grobler, Head of the UFS Department of Genetics.

The UFS Department of Genetics is on par with current research trends in terms of their zebrafish project. About a year has passed since they seriously started focusing on the potential of this tiny four-centimetre-long fish, and the possibilities are hugely exciting.

Looks are deceiving

Leading global genetics laboratories are replacing research on human and animal populations with zebrafish due to several fascinating reasons, of which the most profound is probably that the zebrafish share large portions of its genome with mammals. For genetics researchers this may make a lot of sense, but most people battle to see any resemblance between a six-foot-tall rugby player or 600 kg buffalo and a small, nearly transparent fish. It is in the detail, the researchers say.

Fast, effective, and visible

“The complete genome sequence of the zebrafish is known, and as much as 84% of genes known to be associated with human disease have zebrafish counterparts,” explains Head of Department, Prof Paul Grobler. Another advantage is the fast breeding rate and short generation time, and the fact that some research is ethically more justifiable when done on fish larvae rather than on adult mammals. The fact that zebrafish embryos are virtually transparent, also allow researchers to examine the development of internal structures without effort. Every blood vessel in a living zebrafish embryo is visible under a low-power microscope.

Multidisciplinary

Zebrafish provide research potential for many different study fields besides that of Prof Grobler and his team, Sue Rica Schneider and Dr Willem Coetzer. In the near future, they aim to have undergraduate students use zebrafish as a research model to develop a real sense of research and laboratory work. The Department of Chemistry are also initiating research on zebrafish housed in the Department of Genetics.

News Archive

The first female heart surgeon in South Africa is a Kovsie
2014-12-15


Dr Susan Vosloo is South Africa’s first female heart surgeon. She graduated from the University of the Free State (UFS) in 1980.

“Being a Kovsie student brings back great memories. I received great medical training at the UFS and have fond memories of my time at the university,” she says.

Dr Vosloo completed her internship in Pretoria and spent the following year in Critical Care Medicine at Universitas Hospital, Bloemfontein, before starting her surgical training in Johannesburg.

She is currently in independent private practice at the Netcare Christiaan Barnard Memorial Hospital in Cape Town, having also worked from 1998 – 2012 at the Vincent Pallotti Hospital in the same city.

Dr Vosloo maintains close ties with our university and has quite a number of additional roles to that of surgeon:

• member of the Council of the UFS;
• UFS Council Representative in the Senate;
• member of the Standing Advisory Committee of the School of Medicine, UFS;
• Kovsie Alumnus of the Year (1989);
• member of the Provincial Department of Health;
• Africa representative for the Paediatric Cardiac Intensive Care Society; and
• founding member of the World Society for Paediatric and Congenital Heart Surgery.

“I have always been proud of the medical training I received at Kovsies. I have worked and visited many institutions across the world and never felt less qualified. In fact, all the places I have worked and went to had high regard for the training I received and also accepted me in that way.

“I think the Department of Cardiothoracic Surgery at the UFS does some ground-breaking research that the university can truly be proud of,” Dr Vosloo says.

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