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24 December 2018 | Story Leonie Bolleurs | Photo Anja Aucamp
Research possibilities of zebrafish exposed
Leading global genetics laboratories are replacing research on human and animal populations with zebrafish, says Prof Paul Grobler, Head of the UFS Department of Genetics.

The UFS Department of Genetics is on par with current research trends in terms of their zebrafish project. About a year has passed since they seriously started focusing on the potential of this tiny four-centimetre-long fish, and the possibilities are hugely exciting.

Looks are deceiving

Leading global genetics laboratories are replacing research on human and animal populations with zebrafish due to several fascinating reasons, of which the most profound is probably that the zebrafish share large portions of its genome with mammals. For genetics researchers this may make a lot of sense, but most people battle to see any resemblance between a six-foot-tall rugby player or 600 kg buffalo and a small, nearly transparent fish. It is in the detail, the researchers say.

Fast, effective, and visible

“The complete genome sequence of the zebrafish is known, and as much as 84% of genes known to be associated with human disease have zebrafish counterparts,” explains Head of Department, Prof Paul Grobler. Another advantage is the fast breeding rate and short generation time, and the fact that some research is ethically more justifiable when done on fish larvae rather than on adult mammals. The fact that zebrafish embryos are virtually transparent, also allow researchers to examine the development of internal structures without effort. Every blood vessel in a living zebrafish embryo is visible under a low-power microscope.

Multidisciplinary

Zebrafish provide research potential for many different study fields besides that of Prof Grobler and his team, Sue Rica Schneider and Dr Willem Coetzer. In the near future, they aim to have undergraduate students use zebrafish as a research model to develop a real sense of research and laboratory work. The Department of Chemistry are also initiating research on zebrafish housed in the Department of Genetics.

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An article, co-authored by Kovsies’ own Miss World, Rolene Strauss, was published recently in a medical journal
2015-02-23

Rolene Strauss

The article, which deals with research on the incidence of multiple losses by children, was published in South African Family Practice.

The study was part of the third-year research project for medical students in our Faculty of Health Sciences. Rolene worked with fellow students, Leischen Branders, Mirandie Claassen, Darienne Saaiman, and Andrea van Staden. Prof Gina Joubert from the UFS’s Department of Biostatistics and Prof Hanneke Brits were the module and study leaders.

In this study, a number of cases involving Bloemfontein children experiencing loss, as well as their reaction to it, were examined.

They divided the incidents into categories in order to address the broad definition of ‘losses’.

Approximately 69% of the children in the study have experienced three or more instances of loss in their lives. About 29% of the children have experienced loss in the category Personal Loss (assault, chronic and terminal illness, amputation, malnutrition, disability, abortion, and miscarriage). The greatest number of losses occurred in the category Interpersonal Loss (87%). This group of children has had to deal with the death of one or more parents/caregivers, drug and alcohol abuse, domestic violence, divorce, homelessness, and instability. In the category, Environmental Loss, xenophobia, unsafe living conditions, inadequate support, poverty, and unemployment were looked at. A total of 82% of the children in the group have experienced losses.

Prof Hanneke Brits, study leader of the group, says the extent of multiple losses by children is a topic that hasn’t been investigated widely.

“The study shows that children should receive special attention in order to help them process the trauma. Supportive care and inter-professional services play a major role in this regard.”

 

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