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24 December 2018 | Story Leonie Bolleurs | Photo Anja Aucamp
Research possibilities of zebrafish exposed
Leading global genetics laboratories are replacing research on human and animal populations with zebrafish, says Prof Paul Grobler, Head of the UFS Department of Genetics.
The UFS Department of Genetics is on par with current research trends in terms of their zebrafish project. About a year has passed since they seriously started focusing on the potential of this tiny four-centimetre-long fish, and the possibilities are hugely exciting.

Looks are deceiving

Leading global genetics laboratories are replacing research on human and animal populations with zebrafish due to several fascinating reasons, of which the most profound is probably that the zebrafish share large portions of its genome with mammals. For genetics researchers this may make a lot of sense, but most people battle to see any resemblance between a six-foot-tall rugby player or 600 kg buffalo and a small, nearly transparent fish. It is in the detail, the researchers say.

Fast, effective, and visible

“The complete genome sequence of the zebrafish is known, and as much as 84% of genes known to be associated with human disease have zebrafish counterparts,” explains Head of Department, Prof Paul Grobler. Another advantage is the fast breeding rate and short generation time, and the fact that some research is ethically more justifiable when done on fish larvae rather than on adult mammals. The fact that zebrafish embryos are virtually transparent, also allow researchers to examine the development of internal structures without effort. Every blood vessel in a living zebrafish embryo is visible under a low-power microscope.

Multidisciplinary

Zebrafish provide research potential for many different study fields besides that of Prof Grobler and his team, Sue Rica Schneider and Dr Willem Coetzer. In the near future, they aim to have undergraduate students use zebrafish as a research model to develop a real sense of research and laboratory work. The Department of Chemistry are also initiating research on zebrafish housed in the Department of Genetics.

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News Archive

UFS Autumn Graduation inspires perseverance
2015-04-20

 

Louzanne Coetzee and her guide dog, Oakley after she received her degree at the UFS’s Autumn Graduation.
Photo: Gerhardus Bosch

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Prof Himla Soodyall
Mr Ndumiso Hadebe
Leanne Manas
Dr Maria Phalime
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Autumn has seen the UFS’s first graduation ceremonies of the year on the Bloemfontein Campus. From 14 to 17 April 2015, a total of 3 660 graduates were rewarded for their hard work while top speakers addressed them in the Callie Human Centre.

UFS Chancellor, Dr Khotso Mokhele, commented the more than 250 students who passed their degrees with distinctions at the autumn graduation.

Prof Soodyall, a Medical Scientist at the South African Institute for Medical Research as well as  Principal Medical Scientist for the National Health Laboratory Service, and Director for the Human Genome Diversity and Disease Research Unit at the University of Witwatersrand delivered the first motivational message of the April Graduation. The group of graduates in the Faculty of Natural and Agricultural Sciences listened as she shared her story with them.
 
"My own career – with no grand design or script – steered me into conducting genetic research on human populations from sub-Saharan Africa with a focus on a better understanding of human evolution, and to reconstruct the prehistory of African populations. While giving graduates a glimpse on how her career progressed, Prof Soodyall said: "I share these stories with you to give you some reassurance that you do not need feel that you have to figure out every minute detail of where to from here. Things fall into place with hard work, dedication, and dreams.

The developed world is forging ahead with interventions, so the gap between the developed world and the developing world continues to grow bigger. Prof Soodyall said: “You have the unenviable opportunity to think strategically, and to use the modern tools in your respective fields to make significant advances to transform our society, and to contribute to making it a better place for all. We need to embrace the current challenges, and build networks and bridges across disciplines to close the gaps, to work beyond the cultural barriers, and to ensure equity in access to health, water, education, etc, for all, as we would wish these things for ourselves and our families.

Read the full story of the Autumn Graduation 2015

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