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24 December 2018 | Story Leonie Bolleurs | Photo Anja Aucamp
Research possibilities of zebrafish exposed
Leading global genetics laboratories are replacing research on human and animal populations with zebrafish, says Prof Paul Grobler, Head of the UFS Department of Genetics.

The UFS Department of Genetics is on par with current research trends in terms of their zebrafish project. About a year has passed since they seriously started focusing on the potential of this tiny four-centimetre-long fish, and the possibilities are hugely exciting.

Looks are deceiving

Leading global genetics laboratories are replacing research on human and animal populations with zebrafish due to several fascinating reasons, of which the most profound is probably that the zebrafish share large portions of its genome with mammals. For genetics researchers this may make a lot of sense, but most people battle to see any resemblance between a six-foot-tall rugby player or 600 kg buffalo and a small, nearly transparent fish. It is in the detail, the researchers say.

Fast, effective, and visible

“The complete genome sequence of the zebrafish is known, and as much as 84% of genes known to be associated with human disease have zebrafish counterparts,” explains Head of Department, Prof Paul Grobler. Another advantage is the fast breeding rate and short generation time, and the fact that some research is ethically more justifiable when done on fish larvae rather than on adult mammals. The fact that zebrafish embryos are virtually transparent, also allow researchers to examine the development of internal structures without effort. Every blood vessel in a living zebrafish embryo is visible under a low-power microscope.

Multidisciplinary

Zebrafish provide research potential for many different study fields besides that of Prof Grobler and his team, Sue Rica Schneider and Dr Willem Coetzer. In the near future, they aim to have undergraduate students use zebrafish as a research model to develop a real sense of research and laboratory work. The Department of Chemistry are also initiating research on zebrafish housed in the Department of Genetics.

News Archive

TEDxUFS conference - the highlight of the university’s innovative calendar
2015-08-11


Mmusi Maimane, leader of the Democratic Alliance with co-organisers of TEDxUFS Bonginkosi Leeuw and Lerothodi Molete after his inspirational talk at the event.
Photo: Curtis Nhlamulo Mashimbye

This year’s TEDxUFS speaker lineup persuaded the audience unanimously to question the nature of reality. The Albert Wessels Auditorium on the Bloemfontein Campus was packed with about 200 attendees on Saturday 1 August 2015.

Speakers shared a multiplicity of profound theories and inquisitions, challenging society in general to think out of the box. Melody Mentz, Gil Oved, Ricardo Peach, Pamela Nomvete, Pepe Marais, Mmusi Maimane, Brian Kally, Pieter Geldenhuys, Philippa Tumubweinee, Gareth Cliff, and Angelo Mockie took on to the stage to tackle multidisciplinary concepts as part of the broad ‘Ask Why’ theme.

Innovation mouthpieces share their worldview

Pieter Geldenhuys, the internationally-renowned futurist and Director of the Institute for Technology Strategy, and Innovation proposed that we change our mindsets by neglecting predictability. “We need to look at different models to understand the world around us,” he said. He challenged the linear and familiar ways humans make sense of the universe.

Speaking to the dire need for transformation, Philippa Tumubweinee suggested that university spaces merge with the communities they serve in terms of policies, social atmosphere, and physical structure. Tumubweinee is a senior Lecturer at the Department of Architecture at our university, and co-Founder and Director of Izuba In Africa architects.

“Only we can give permission to be intimidated; so don’t give in,” said Brian Kally, the CEO of Arrow Logistics (Pty) Ltd. Kally underscored the power of believing in our individual ideas.

Guidelines from TEDxUFS organisers

Bonginkosi Leeuw: “If you take your brainchild and implement it, and make it a reality, that’s when you can achieve great things, not before that.”

Lerothodi Molete: “You should ask questions; the moment you ask the question you will understand more.”

Real-time social media feedback

These are some of the comments audience members published on Twitter at the event:

IG: mispertanzy ?@MiesperTanzy  Aug 1

A huge shout-out to @TEDxUFS for hosting such a great conference!The team has really made the event an unmissable one on the UFS calendar.

Celebrabitur? ?@HatsuMphatsoe  Aug 1

Proximity that allows us to experience our broader society. Truly engaged by Philippa Tumbweinee's talk! @TEDxUFS

TEDxJohannesburg ?@TEDxJoburg  Aug 1

A big shoutout to @TEDxUFS from for a fantastic event. Wish we were there.

RicardoPeach ?@ricardopeach  Aug 1

Africa is rich with potential  #TEDXUFS @MmusiMaimane Yes!

 

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