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24 December 2018 | Story Leonie Bolleurs | Photo Anja Aucamp
Research possibilities of zebrafish exposed
Leading global genetics laboratories are replacing research on human and animal populations with zebrafish, says Prof Paul Grobler, Head of the UFS Department of Genetics.

The UFS Department of Genetics is on par with current research trends in terms of their zebrafish project. About a year has passed since they seriously started focusing on the potential of this tiny four-centimetre-long fish, and the possibilities are hugely exciting.

Looks are deceiving

Leading global genetics laboratories are replacing research on human and animal populations with zebrafish due to several fascinating reasons, of which the most profound is probably that the zebrafish share large portions of its genome with mammals. For genetics researchers this may make a lot of sense, but most people battle to see any resemblance between a six-foot-tall rugby player or 600 kg buffalo and a small, nearly transparent fish. It is in the detail, the researchers say.

Fast, effective, and visible

“The complete genome sequence of the zebrafish is known, and as much as 84% of genes known to be associated with human disease have zebrafish counterparts,” explains Head of Department, Prof Paul Grobler. Another advantage is the fast breeding rate and short generation time, and the fact that some research is ethically more justifiable when done on fish larvae rather than on adult mammals. The fact that zebrafish embryos are virtually transparent, also allow researchers to examine the development of internal structures without effort. Every blood vessel in a living zebrafish embryo is visible under a low-power microscope.

Multidisciplinary

Zebrafish provide research potential for many different study fields besides that of Prof Grobler and his team, Sue Rica Schneider and Dr Willem Coetzer. In the near future, they aim to have undergraduate students use zebrafish as a research model to develop a real sense of research and laboratory work. The Department of Chemistry are also initiating research on zebrafish housed in the Department of Genetics.

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Three minutes for research
2015-08-19

Sixty-three researchers, three minutes each. This is the Three-Minute-Thesis competition (3MT) for master’s and doctoral students countrywide, presented by the Postgraduate School at the University of the Free State.

For the first time, this international competition will be presented on a national level in South Africa, with students from more than ten of the most prominent universities in the country taking part. During the competition, each researcher has to give a presentation on his/her research in three minutes.

Mr Katleho Nyaile, the competition organiser, says the 3MT is part of the Postgraduate School’s initiative to highlight and to boost postgraduate research.

The 3MT competition originated at the University of Queensland, Australia. Since its inception in 2010, it has developed into an international trend. Currently, the 3MT is presented in Australia, the USA, and the UK.

For the competition, participants are given only three minutes to explain their research. In this short time, they have to explain not only the problem and the methodology, but also why this research is important. Participants are allowed to make use of only one piece of static imaging material for support.

“It is not only great fun, but also a learning opportunity for the researchers. The competition supports the capacity of the researchers to convey the essence of their theses effectively. This is something that researchers sometimes find very difficult.”

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