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24 December 2018 | Story Leonie Bolleurs | Photo Anja Aucamp
Research possibilities of zebrafish exposed
Leading global genetics laboratories are replacing research on human and animal populations with zebrafish, says Prof Paul Grobler, Head of the UFS Department of Genetics.

The UFS Department of Genetics is on par with current research trends in terms of their zebrafish project. About a year has passed since they seriously started focusing on the potential of this tiny four-centimetre-long fish, and the possibilities are hugely exciting.

Looks are deceiving

Leading global genetics laboratories are replacing research on human and animal populations with zebrafish due to several fascinating reasons, of which the most profound is probably that the zebrafish share large portions of its genome with mammals. For genetics researchers this may make a lot of sense, but most people battle to see any resemblance between a six-foot-tall rugby player or 600 kg buffalo and a small, nearly transparent fish. It is in the detail, the researchers say.

Fast, effective, and visible

“The complete genome sequence of the zebrafish is known, and as much as 84% of genes known to be associated with human disease have zebrafish counterparts,” explains Head of Department, Prof Paul Grobler. Another advantage is the fast breeding rate and short generation time, and the fact that some research is ethically more justifiable when done on fish larvae rather than on adult mammals. The fact that zebrafish embryos are virtually transparent, also allow researchers to examine the development of internal structures without effort. Every blood vessel in a living zebrafish embryo is visible under a low-power microscope.

Multidisciplinary

Zebrafish provide research potential for many different study fields besides that of Prof Grobler and his team, Sue Rica Schneider and Dr Willem Coetzer. In the near future, they aim to have undergraduate students use zebrafish as a research model to develop a real sense of research and laboratory work. The Department of Chemistry are also initiating research on zebrafish housed in the Department of Genetics.

News Archive

Student gives hope to childhood cancer patients
2015-10-16


Siphokuhle Jama believes that the underprivileged are also destined to reign.

The inaugural ‘Dance and Musical Childhood Cancer Fundraising Day’, held on Saturday 26 September 2015 at the Free State Childhood Cancer (CHOC) Foundation, was “a huge success,” according to Siphokuhle Jama, the organiser.

Siphokuhle is a second-year BSc Agricultural Economics student at the University of the Free State (UFS), who has devoted his life to bettering the lives of the less fortunate. The 21-year-old self-proclaimed motivational speaker, entrepreneur, and budding author was inspired by his humble beginnings to found the Destined to Reign Foundation, which champions various community initiatives in both his home town of Mtata and Bloemfontein.

To support the fight against childhood cancer, the young philanthropist took it upon himself to invite music and dance fanatics either to perform or to enjoy spectatorship for a good cause. The impressive support received from the UFS, Universitas Academic Hospital, and Central University of Technology (CUT), various artists, and the community has contributed towards ensuring that the inaugural fundraiser was a prelude to annual events to come.

Singers, dancers, and poets entertained the audience with vigour, making the day one of the most special for the young children, who spend their days and nights at the CHOC House, with little to do but undergo radiation and chemotherapy and await a discharge date. .

All proceeds went towards basic needs, such as food, toiletries, and clothing for the children residing at the House, which is located in the same suburb as our university. In addition to accommodating dozens of cancer patients and their mothers, the House also assists with the treatment and rehabilitation of children suffering from life-threatening blood disorders. Thus, the fundraiser served to promote awareness of these health conditions.

Siphokuhle’s passion for giving hope to the underprivileged was unveiled by a school community engagement project 14 years ago. He has never looked back.“It has always been in my heart to serve my community,” he said.

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