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24 December 2018 | Story Leonie Bolleurs | Photo Anja Aucamp
Research possibilities of zebrafish exposed
Leading global genetics laboratories are replacing research on human and animal populations with zebrafish, says Prof Paul Grobler, Head of the UFS Department of Genetics.

The UFS Department of Genetics is on par with current research trends in terms of their zebrafish project. About a year has passed since they seriously started focusing on the potential of this tiny four-centimetre-long fish, and the possibilities are hugely exciting.

Looks are deceiving

Leading global genetics laboratories are replacing research on human and animal populations with zebrafish due to several fascinating reasons, of which the most profound is probably that the zebrafish share large portions of its genome with mammals. For genetics researchers this may make a lot of sense, but most people battle to see any resemblance between a six-foot-tall rugby player or 600 kg buffalo and a small, nearly transparent fish. It is in the detail, the researchers say.

Fast, effective, and visible

“The complete genome sequence of the zebrafish is known, and as much as 84% of genes known to be associated with human disease have zebrafish counterparts,” explains Head of Department, Prof Paul Grobler. Another advantage is the fast breeding rate and short generation time, and the fact that some research is ethically more justifiable when done on fish larvae rather than on adult mammals. The fact that zebrafish embryos are virtually transparent, also allow researchers to examine the development of internal structures without effort. Every blood vessel in a living zebrafish embryo is visible under a low-power microscope.

Multidisciplinary

Zebrafish provide research potential for many different study fields besides that of Prof Grobler and his team, Sue Rica Schneider and Dr Willem Coetzer. In the near future, they aim to have undergraduate students use zebrafish as a research model to develop a real sense of research and laboratory work. The Department of Chemistry are also initiating research on zebrafish housed in the Department of Genetics.

News Archive

Department of Education prescribes student’s novel to schools
2015-11-03


Ntshala Mahasa: The young storyteller

Three years ago Ntshala Mahase was an ordinary high school learner studying texts prescribed by the Department of Education. Now, other learners will be reading his brainchild, Life out of the Ordinary.

The third-year LLB student at the University of the Free State (UFS) officially launched his debut novel in July 2015 at the Bloemfontein Campus. Three months later, the work of fiction has reached a milestone of note. The novel has been selected as one of 12 books from young and emerging writers to form part of the Library and Information Association of South Africa’s (LIASA) Young Writers Programme.

LIASA is the regulatory body for South African public, school, and university libraries. Ntshala’s literary contribution is to be distributed to different school libraries, as per decision of the Western Cape and Gauteng Departments of Education.

About the book

The book narrates the transformational journey of a privileged suburban school boy who one day coincidently exposes himself to the harsh realities of an impoverished South African community. Tom then decides to make a difference and assist those who are less privileged. His experience out of his ordinary and secured Hyde Park life shakes him to such an extent that he falls into emotional anxiety and depression.

One in a thousand

Out of more than 200 entries, Life out of the Ordinary emerged as the only entry from outside the borders of the two provinces to make a set of 1 000 books recommended by LIASA to be prescribed by public schools as of 2016.

Ntshala was taken aback by the enthusiastic reception which his story attracted. “I am greatly humbled.This means it will rub shoulders with books by great South African authors like Niq Mhlongo, Zukiswa Wanner, Thando Mgqolozana, Zakes Mda and the likes,” he said. He is currently authoring his second novel.

 

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