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24 December 2018 | Story Leonie Bolleurs | Photo Anja Aucamp
Research possibilities of zebrafish exposed
Leading global genetics laboratories are replacing research on human and animal populations with zebrafish, says Prof Paul Grobler, Head of the UFS Department of Genetics.
The UFS Department of Genetics is on par with current research trends in terms of their zebrafish project. About a year has passed since they seriously started focusing on the potential of this tiny four-centimetre-long fish, and the possibilities are hugely exciting.

Looks are deceiving

Leading global genetics laboratories are replacing research on human and animal populations with zebrafish due to several fascinating reasons, of which the most profound is probably that the zebrafish share large portions of its genome with mammals. For genetics researchers this may make a lot of sense, but most people battle to see any resemblance between a six-foot-tall rugby player or 600 kg buffalo and a small, nearly transparent fish. It is in the detail, the researchers say.

Fast, effective, and visible

“The complete genome sequence of the zebrafish is known, and as much as 84% of genes known to be associated with human disease have zebrafish counterparts,” explains Head of Department, Prof Paul Grobler. Another advantage is the fast breeding rate and short generation time, and the fact that some research is ethically more justifiable when done on fish larvae rather than on adult mammals. The fact that zebrafish embryos are virtually transparent, also allow researchers to examine the development of internal structures without effort. Every blood vessel in a living zebrafish embryo is visible under a low-power microscope.

Multidisciplinary

Zebrafish provide research potential for many different study fields besides that of Prof Grobler and his team, Sue Rica Schneider and Dr Willem Coetzer. In the near future, they aim to have undergraduate students use zebrafish as a research model to develop a real sense of research and laboratory work. The Department of Chemistry are also initiating research on zebrafish housed in the Department of Genetics.

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News Archive

State-of-the-art audio-visual studio up and running at UFS
2015-11-25

The state-of-the-art audio-visual studio that was unveiled in the beginning of this year reaped its first crop during a historic moment. On Wednesday 28 October 2015, the eight pilot students in the Postgraduate Programme in Film and Visual Media, which was launched at the beginning of this year, had their first big screen experience. Eight films were premiered in one night at the University of the Free State (UFS) Bloemfontein Campus.

An intimate movie theatre was brimming with friends and family of the students, their lecturers, and judges who doubled as moderators. This was no ordinary motion picture viewing. The apprentice filmmakers’ productions were undergoing formal external examination.

Judge by a legend

Katinka Heyns critiqued the student’s final products. Heyns is a renowned filmmaker, actress, director, producer, and founder of the production company, Sonneblom Films. She has numerous awards to her name, including the Career Contribution and Innovation Award, Legendary Award for Woman in Film and Television, and Medal of Honour for Paljas, which were presented by the Absa Klein Karoo Nasionale Kunstefees (KKNK), International Crystal Award, and South African Academy for Science and Arts, respectively.

Johanet Kriel and Chris Vorster from the film school also assisted as moderators.



The cinema exam

Each student had 20 minutes to provide a synopsis for the viewers, and screen the movie. At the end, The Secret of the Golden Flower, written and directed by Rudiker Janse van Rensburg, and The Nexus Effect, written and directed by Gawie Myburgh were judged the best movies “Both films had had clear and creative story lines, a solid structure, and quality editing,” said Chris Vorster.

Despite technical teething problems, all the students showed a great deal of talent and passion for filmmaking. “Given the time constraints and technical challenges, I’m very relieved that we actually got films on screen. They all impressed me with their creativity. Mission accomplished,” added Vorster.

The films

• The Blood of Barbara (Yvonne Allwright)
• Diary of an Oreo (Nonsindiso Qwabe)
• GeFop! (Hendrik Cronje)
• The Nexus Effect (Gawie Myburgh)
• The Secret of the Golden Flower (Rudiker Janse van Rensburg)
• Well ain’t that a Coinkydink?! (Rethabile Radebe)
• What Lurks in the Dark…(Rese Moore)

(Photo caption: Front row from left: Nonsindiso Qwabe, Suné van Heerden, Theresa Moore, Gawie Myburgh. Middle row: Rudiker Janse van Rensburg, Hendrik Cronjé, Yvonne Allwright, and Rethabile Radebe. Back: lecturer: Chris Vorster.)

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