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24 December 2018 | Story Leonie Bolleurs | Photo Anja Aucamp
Research possibilities of zebrafish exposed
Leading global genetics laboratories are replacing research on human and animal populations with zebrafish, says Prof Paul Grobler, Head of the UFS Department of Genetics.

The UFS Department of Genetics is on par with current research trends in terms of their zebrafish project. About a year has passed since they seriously started focusing on the potential of this tiny four-centimetre-long fish, and the possibilities are hugely exciting.

Looks are deceiving

Leading global genetics laboratories are replacing research on human and animal populations with zebrafish due to several fascinating reasons, of which the most profound is probably that the zebrafish share large portions of its genome with mammals. For genetics researchers this may make a lot of sense, but most people battle to see any resemblance between a six-foot-tall rugby player or 600 kg buffalo and a small, nearly transparent fish. It is in the detail, the researchers say.

Fast, effective, and visible

“The complete genome sequence of the zebrafish is known, and as much as 84% of genes known to be associated with human disease have zebrafish counterparts,” explains Head of Department, Prof Paul Grobler. Another advantage is the fast breeding rate and short generation time, and the fact that some research is ethically more justifiable when done on fish larvae rather than on adult mammals. The fact that zebrafish embryos are virtually transparent, also allow researchers to examine the development of internal structures without effort. Every blood vessel in a living zebrafish embryo is visible under a low-power microscope.

Multidisciplinary

Zebrafish provide research potential for many different study fields besides that of Prof Grobler and his team, Sue Rica Schneider and Dr Willem Coetzer. In the near future, they aim to have undergraduate students use zebrafish as a research model to develop a real sense of research and laboratory work. The Department of Chemistry are also initiating research on zebrafish housed in the Department of Genetics.

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Researcher in Otorhinolaryngology advocates education in deafness and hearing loss
2015-12-17

Description: Dr Magteld Smith  Tags: Dr Magteld Smith

Dr Magteld Smith

The annual International Day of Persons with Disabilities falls on 3 December. Statistics reveal that 7.5% of the South African population suffer from some form of physical disability.

More than 17 million people in South Africa are dealing with depression, substance abuse, anxiety, bipolar disorder, and schizophrenia - illnesses that round out the top five mental health diagnoses, according to the Mental Health Federation of South Africa. The South African Federation for Mental Health is the umbrella body for 17 mental health societies and numerous member organisations throughout the country.

On disability, world-renowned author Helen Keller, who was both deaf and blind, once said that the problems that come with being deaf are deeper and more complex than those of blindness, and is a much worse misfortune. For it means the loss of the most vital stimulus - the sound of the voice that brings language, sets thoughts astir, and keeps us in the intellectual company of man.

According to Dr Magteld Smith, lecturer and researcher in the Department of Otorhinolaryngology at the University of the Free State (UFS), hearing loss of any degree at any age can have far-reaching psychological and sociological implications which affect an individual’s day-to-day functioning, and might prevent him or her from reaching their full potential. She says that even though advancements have been made in aiding deaf persons, there’s still considerable room for improvement. She’s making it her mission to bring about changing the stigmatisation around deafness, and the different choices of rehabilitation.

Dr Smith was born with bilateral (both ears) severe hearing loss, and became profoundly deaf, receiving a cochlear implant in 2008. Not letting this hinder her quality of life, she matriculated in 1985 at a School for the Deaf in Worcester. Today she is the only deaf medical-social researcher in South Africa.

Her research focuses on all aspects of deafness and hearing loss. Through first-hand experience, she knows that a loss of hearing can be traumatic as it requires adjustments in many areas of life which affect a person’s entire development. However, she has not let her deafness become a stumbling block. She has become the first deaf South African to obtain two Master’s degrees and a PhD, together with various other achievements.

Her work is aimed at informing and educating people in the medical profession, parents with children, and persons with various degrees and types of hearing loss about the complexities of deafness and hearing loss. She believes that, with the technological advancements that have been made in the world, deaf people can become self-sufficient and independent world changers with much to contribute to humanity.

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