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24 December 2018 | Story Leonie Bolleurs | Photo Anja Aucamp
Research possibilities of zebrafish exposed
Leading global genetics laboratories are replacing research on human and animal populations with zebrafish, says Prof Paul Grobler, Head of the UFS Department of Genetics.

The UFS Department of Genetics is on par with current research trends in terms of their zebrafish project. About a year has passed since they seriously started focusing on the potential of this tiny four-centimetre-long fish, and the possibilities are hugely exciting.

Looks are deceiving

Leading global genetics laboratories are replacing research on human and animal populations with zebrafish due to several fascinating reasons, of which the most profound is probably that the zebrafish share large portions of its genome with mammals. For genetics researchers this may make a lot of sense, but most people battle to see any resemblance between a six-foot-tall rugby player or 600 kg buffalo and a small, nearly transparent fish. It is in the detail, the researchers say.

Fast, effective, and visible

“The complete genome sequence of the zebrafish is known, and as much as 84% of genes known to be associated with human disease have zebrafish counterparts,” explains Head of Department, Prof Paul Grobler. Another advantage is the fast breeding rate and short generation time, and the fact that some research is ethically more justifiable when done on fish larvae rather than on adult mammals. The fact that zebrafish embryos are virtually transparent, also allow researchers to examine the development of internal structures without effort. Every blood vessel in a living zebrafish embryo is visible under a low-power microscope.

Multidisciplinary

Zebrafish provide research potential for many different study fields besides that of Prof Grobler and his team, Sue Rica Schneider and Dr Willem Coetzer. In the near future, they aim to have undergraduate students use zebrafish as a research model to develop a real sense of research and laboratory work. The Department of Chemistry are also initiating research on zebrafish housed in the Department of Genetics.

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Prof Luyt says young researchers should not allow circumstances to determine their future
2016-02-01

Description: Prof Riaan Luyt Tags: Prof Riaan Luyt

Prof Riaan Luyt, an NRF B-rated researcher
Photo: Supplied

Young researchers, who spend their life at a disadvantaged and rural campus like the University of the Free State’s Qwaqwa Campus, should not be deterred from achieving their dreams.

This is the view of Prof Riaan Luyt, former Assistant Dean in the Faculty of Natural and Agricultural Sciences, who achieved his B-rating by the National Research Foundation (NRF) late in 2015. This was by far the highest-ever rating on the Qwaqwa Campus.

“When I moved to the Qwaqwa Campus many years ago, having had the opportunity to do a post-doctoral fellowship in Polymer Science at the Leeds University in the United Kingdom, I was determined to get the Department of Chemistry off the ground, and to embark on serious research,” said Prof Luyt, who is now the Affiliated Professor in the Department of Chemistry and Research Associate Professor at the Centre for Advanced Materials, based at Qatar University.

“It was through sheer determination that I managed to obtain enough funds to equip a decent research laboratory. There were many obstacles over the years, but I managed to attract more and more postgraduate students and published more,” he said.

At first, Prof Luyt was not successful with his NRF-rating applications.

“My first couple of attempts to get rated produced no success. I was then awarded a C3-rating, which was later followed by C2 and then C1,” he added. “Getting a B-rating is the highlight of my research career. It shows that it can be done. Young researchers should not allow their past or present circumstances, or their work environment to stand on their way,” said Prof Luyt, who has supervised 38 master’s and doctoral students as well as 11 postdoctoral fellows. He has also published 185 papers in international and accredited journals.

Although abroad, Prof Luyt will continue to supervise eight postgraduate students at the Qwaqwa Campus.

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