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24 December 2018 | Story Leonie Bolleurs | Photo Anja Aucamp
Research possibilities of zebrafish exposed
Leading global genetics laboratories are replacing research on human and animal populations with zebrafish, says Prof Paul Grobler, Head of the UFS Department of Genetics.

The UFS Department of Genetics is on par with current research trends in terms of their zebrafish project. About a year has passed since they seriously started focusing on the potential of this tiny four-centimetre-long fish, and the possibilities are hugely exciting.

Looks are deceiving

Leading global genetics laboratories are replacing research on human and animal populations with zebrafish due to several fascinating reasons, of which the most profound is probably that the zebrafish share large portions of its genome with mammals. For genetics researchers this may make a lot of sense, but most people battle to see any resemblance between a six-foot-tall rugby player or 600 kg buffalo and a small, nearly transparent fish. It is in the detail, the researchers say.

Fast, effective, and visible

“The complete genome sequence of the zebrafish is known, and as much as 84% of genes known to be associated with human disease have zebrafish counterparts,” explains Head of Department, Prof Paul Grobler. Another advantage is the fast breeding rate and short generation time, and the fact that some research is ethically more justifiable when done on fish larvae rather than on adult mammals. The fact that zebrafish embryos are virtually transparent, also allow researchers to examine the development of internal structures without effort. Every blood vessel in a living zebrafish embryo is visible under a low-power microscope.

Multidisciplinary

Zebrafish provide research potential for many different study fields besides that of Prof Grobler and his team, Sue Rica Schneider and Dr Willem Coetzer. In the near future, they aim to have undergraduate students use zebrafish as a research model to develop a real sense of research and laboratory work. The Department of Chemistry are also initiating research on zebrafish housed in the Department of Genetics.

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SARChI Chair on disease resistance and quality in field crops awarded in UFS Department of Plant Science
2016-02-01

Description: SARChI Chair  Tags: SARChI Chair

Prof Labuschagne

A South African Research Chairs Initiative (SARChI) chair has been awarded in the Department of Plant Sciences at the University of the Free State (UFS). The chair will be headed by Prof Maryke Labuschagne, and will focus on crop quality breeding and disease resistance in field crops.

The disease resistance research by the chair will be headed by Prof Zakkie Pretorius. The disease resistance breeding will be a continuation of the internationally-acclaimed wheat rust research that Prof Pretorius has been conducting during his career.

The quality breeding will focus on crop protein quantity and quality as well as on iron, zinc, and beta carotene biofortification of staple crops such as wheat, maize, and cassava.

Prof Labuschagne believes that food security is one of the key factors for stability and prosperity on the continent. Her research and that of her students focuses on the genetic improvement of food security crops in Africa, including such staples as maize and cassava. “These crops are genetically improved for yield, drought tolerance, disease, and insect resistance, as well nutritional value,” she said.

Last year, one of  Prof Labuschagne’s PhD students, Bright Peprah, received an award for $473 000 from the competitive Program for Emerging Agricultural Research Leaders (PEARL) of the Bill and Melinda Gates Foundation for his project on improving the beta-carotene content in cassava.

Prof Labuschagne also received the prestigious ‘Continental Lifetime Achiever Award’ from Africa’s Most Influential Women in Business and Government Programme (MIW) last year for her commitment and continuous contributions to food security. She is an NRF-rated researcher, and author or co-author of over 160 articles in accredited journals.

Research Chairs have been designed by the Department of Science and Technology, together with the National Research Foundation, to attract and retain excellence in research and innovation at South African public universities. 

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