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24 December 2018 | Story Leonie Bolleurs | Photo Anja Aucamp
Research possibilities of zebrafish exposed
Leading global genetics laboratories are replacing research on human and animal populations with zebrafish, says Prof Paul Grobler, Head of the UFS Department of Genetics.

The UFS Department of Genetics is on par with current research trends in terms of their zebrafish project. About a year has passed since they seriously started focusing on the potential of this tiny four-centimetre-long fish, and the possibilities are hugely exciting.

Looks are deceiving

Leading global genetics laboratories are replacing research on human and animal populations with zebrafish due to several fascinating reasons, of which the most profound is probably that the zebrafish share large portions of its genome with mammals. For genetics researchers this may make a lot of sense, but most people battle to see any resemblance between a six-foot-tall rugby player or 600 kg buffalo and a small, nearly transparent fish. It is in the detail, the researchers say.

Fast, effective, and visible

“The complete genome sequence of the zebrafish is known, and as much as 84% of genes known to be associated with human disease have zebrafish counterparts,” explains Head of Department, Prof Paul Grobler. Another advantage is the fast breeding rate and short generation time, and the fact that some research is ethically more justifiable when done on fish larvae rather than on adult mammals. The fact that zebrafish embryos are virtually transparent, also allow researchers to examine the development of internal structures without effort. Every blood vessel in a living zebrafish embryo is visible under a low-power microscope.

Multidisciplinary

Zebrafish provide research potential for many different study fields besides that of Prof Grobler and his team, Sue Rica Schneider and Dr Willem Coetzer. In the near future, they aim to have undergraduate students use zebrafish as a research model to develop a real sense of research and laboratory work. The Department of Chemistry are also initiating research on zebrafish housed in the Department of Genetics.

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Female-headed households more prone to economic strains due to rainfall variations
2016-02-02

Description: Martin Flatø  Tags: Martin Flatø

Martin Flatø
Photo: University of Oslo press

Research shows that a total of 41 % of South African (SA) households are led by women, and these households are twice as likely to be poor compared to other households.

Martin Flatø spent three months at University of the Free State (UFS), researching how female-headed households in our country are affected by variations in rainfall, which cause crop failures with their implications for rural economies.

He is a PhD student from the University of Oslo in Norway who was part of the 2014/15 Southern African Young Scientists Summer Programme (SA-YSSP) that was hosted by the UFS last year.

Flatø formed part of a group of international scholars who conducted research on how families led by females are affected by climate change. The group focused on the implications of the weather on crop failures and rural economies. Gender and household structures were studied to determine ways in which they are affected by economic fluctuations.
 
The research group’s preliminary findings indicate that female-headed households are more vulnerable to rainfall variation than households where there are adult residents or workers of both genders.

In view of the current water shortage in the Free State, as well as scientists’ projections that our country will be among the regions hardest hit by climate change in terms of a surge in temperature, Flatø’s collaborative research has substantial relevance.|

Grooming first class scientists
The SA-YSSP is a joint initiative of South African National Research Foundation and the International Institute of Applied Systems Analysis (IIASA). Its main aim is tackling challenges faced by the world at large and South Africa in particular.

Out of 24 PhD students from 18 countries and various academic disciplines, Flatø emerged as one of only three scholars to be awarded the Systems Analysis Scholarships for his outstanding science at the end of the programme.

World class mentorship
Prof André Pelser and Dr Raya Muttarak were Flatø’s SA-YSSP supervisors. Prof Pelser, of the UFS Department of Sociology, is a leading academic on population processes, and how they relate to local environmental issues in South Africa. Dr Muttarak is a research scholar at IIASA in Austria.

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