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24 December 2018 | Story Leonie Bolleurs | Photo Anja Aucamp
Research possibilities of zebrafish exposed
Leading global genetics laboratories are replacing research on human and animal populations with zebrafish, says Prof Paul Grobler, Head of the UFS Department of Genetics.

The UFS Department of Genetics is on par with current research trends in terms of their zebrafish project. About a year has passed since they seriously started focusing on the potential of this tiny four-centimetre-long fish, and the possibilities are hugely exciting.

Looks are deceiving

Leading global genetics laboratories are replacing research on human and animal populations with zebrafish due to several fascinating reasons, of which the most profound is probably that the zebrafish share large portions of its genome with mammals. For genetics researchers this may make a lot of sense, but most people battle to see any resemblance between a six-foot-tall rugby player or 600 kg buffalo and a small, nearly transparent fish. It is in the detail, the researchers say.

Fast, effective, and visible

“The complete genome sequence of the zebrafish is known, and as much as 84% of genes known to be associated with human disease have zebrafish counterparts,” explains Head of Department, Prof Paul Grobler. Another advantage is the fast breeding rate and short generation time, and the fact that some research is ethically more justifiable when done on fish larvae rather than on adult mammals. The fact that zebrafish embryos are virtually transparent, also allow researchers to examine the development of internal structures without effort. Every blood vessel in a living zebrafish embryo is visible under a low-power microscope.

Multidisciplinary

Zebrafish provide research potential for many different study fields besides that of Prof Grobler and his team, Sue Rica Schneider and Dr Willem Coetzer. In the near future, they aim to have undergraduate students use zebrafish as a research model to develop a real sense of research and laboratory work. The Department of Chemistry are also initiating research on zebrafish housed in the Department of Genetics.

News Archive

Shimlas shock Tuks by staying calm
2016-02-19

Description: KL News 2016 02 19  Varsitycup Tags: KL News 2016 02 19  Varsitycup
Prop Ox Nche was one of the substitutes who had a huge impact against Tuks in Pretoria on 15 February 2016. Nche and other Shimlas substitutes helped their team wipe out a massive deficit. Photo: Johan Roux.

He has never been involved in a match like this in his rugby career.
This is what Neil Claassen had to say about his team’s performance on 15 February 2016, when the Shimlas came up with one of the biggest fight-backs in the history of the Varsity Cup in Pretoria. According to the Shimlas Captain, his bench had a great impact, and this helped in shocking Tuks with 47-46 towards the end. This came after Tuks had been leading 43-15 in the 44th minute.

Great fighting spirit
The Shimlas' fighting spirit, and a new Varsity Cup points system in which converted tries may count up to 11 points, enabled them to wipe out this deficit.
“It was a tough match, especially after being so far behind,” Neil said.
“Coach (Hendro Scholtz) told us during half-time (when we were 15-36 behind) that we should stay calm."
“We weren't completely out of the game. We knew that if we eliminated unnecessary mistakes, we could make it.”

Impact from bench
This is the second consecutive match - the other was against Ikeys in Cape Town - where the Shimlas’ substitutes swayed the match. “The bench made a big difference,” Neil said. “We also scored an 11-point try, which helped a lot.”
The Shimlas’ fullback, Marco Mason, was named Player of the Match. He succeeded with a tricky conversion to gain victory for his team.

Injuries
The eighth man, Nardus Erasmus (knee) and flanker, Fiffy Rampeta (eye socket), sustained injuries, but should be able to play in the first home game against the Madibaz on 22 February 2016. The injured scrumhalf, Zee Mkhabela (concussion), could return for this match.
Shimlas are second on the log, with nine league points after two away matches. Maties has ten league points.

Young Guns get stuck
The University of the Free State (UFS') Young Guns got stuck 8-14 against Tuks in Pretoria on 15 February 2016.
Vishuis, the UFS's residence team, will start their onslaught in the residence league against Dagbreek in Stellenbosch on 22 February 2016.

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