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24 December 2018 | Story Leonie Bolleurs | Photo Anja Aucamp
Research possibilities of zebrafish exposed
Leading global genetics laboratories are replacing research on human and animal populations with zebrafish, says Prof Paul Grobler, Head of the UFS Department of Genetics.

The UFS Department of Genetics is on par with current research trends in terms of their zebrafish project. About a year has passed since they seriously started focusing on the potential of this tiny four-centimetre-long fish, and the possibilities are hugely exciting.

Looks are deceiving

Leading global genetics laboratories are replacing research on human and animal populations with zebrafish due to several fascinating reasons, of which the most profound is probably that the zebrafish share large portions of its genome with mammals. For genetics researchers this may make a lot of sense, but most people battle to see any resemblance between a six-foot-tall rugby player or 600 kg buffalo and a small, nearly transparent fish. It is in the detail, the researchers say.

Fast, effective, and visible

“The complete genome sequence of the zebrafish is known, and as much as 84% of genes known to be associated with human disease have zebrafish counterparts,” explains Head of Department, Prof Paul Grobler. Another advantage is the fast breeding rate and short generation time, and the fact that some research is ethically more justifiable when done on fish larvae rather than on adult mammals. The fact that zebrafish embryos are virtually transparent, also allow researchers to examine the development of internal structures without effort. Every blood vessel in a living zebrafish embryo is visible under a low-power microscope.

Multidisciplinary

Zebrafish provide research potential for many different study fields besides that of Prof Grobler and his team, Sue Rica Schneider and Dr Willem Coetzer. In the near future, they aim to have undergraduate students use zebrafish as a research model to develop a real sense of research and laboratory work. The Department of Chemistry are also initiating research on zebrafish housed in the Department of Genetics.

News Archive

Maize breeder rewarded for his research to enhance food security in Africa
2016-08-26

Description: Maize breeder rewarded  Tags: Maize breeder rewarded

Prof Maryke Labuschagne from the UFS Department
of Plant Sciences, Berhanu Tadesse Ertiro, a
postgraduate student in Plant breeding at the UFS,
and Dr Peg Redinbaugh of the US Department of
Agriculture in Wooster, Ohio.
Photo: Supplied

Ethiopia is one of the African countries, deeply affected by food insecurity. Berhanu Tadesse Ertiro, a citizen from Ethiopia started his career - after graduating with his undergraduate degree in 2003 - as a junior maize breeder. Today he is pursuing his doctorate degree in Plant Breeding at the University of the Free State (UFS).

His research had made some great strides in contributing to food security in Africa. He recently received a fellowship from the prestigious Norman E. Borlaug Leadership Enhancement in Agriculture Program (Borlaug LEAP).

This fellowship is only awarded to students whose research has relevance to the national development of the student’s home country or region. The aim of these fellowships are to enhance the quality of thesis research of graduate students from developing countries who show strong promise as leaders in the field of agriculture and related disciplines.

Low soil fertility a major maize production constraint
Berhanu is also a visiting student at the International Maize and Wheat Improvement Center (CIMMYT) in Kenya, where he is running field experiments for his PhD thesis dissertation. His research focuses on Nitrogen Use Efficiency (NUE) and Maize Lethal Necrosis (MLN) disease tolerance. Low soil fertility and MLN are among the major maize production constraints in eastern and southern Africa, where maize is staple food.

Such hybrids have the potential to contribute greatly
towards food security among farmers and their
families through increased productivity.

The use of new tools could increase breeding efficiency and reduce the time needed for the release of new stress tolerant hybrids. Such hybrids have the potential to contribute greatly towards food security among farmers and their families through increased productivity. Berhanu is looking at the feasibility of genome wide selection for improvement of NUE in tropical maize.

Fellowship includes mentorship and supervision across borders
The programme supports engaging a mentor at a United States university and Consortium of International Agricultural Research Centers (CGIAR). During his fellowship, he will be supervised and mentored by Prof Maryke Labuschagne of the UFS, Prof Rex Bernando, a professor of Corn Breeding and Genetics at the University of Minnesota and Dr Biswanath Das of CIMMYT, Kenya.

As a LEAP fellow, Berhanu was invited to attend the 30th Annual World Food Prize events to take place in October 2016, in Des Moines, Iowa. The week will include his attendance at the Board for International Food and Agricultural Development meeting, participation at side-events at the Borlaug Dialogue International Symposium and the World Food Prize.

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