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24 December 2018 | Story Leonie Bolleurs | Photo Anja Aucamp
Research possibilities of zebrafish exposed
Leading global genetics laboratories are replacing research on human and animal populations with zebrafish, says Prof Paul Grobler, Head of the UFS Department of Genetics.

The UFS Department of Genetics is on par with current research trends in terms of their zebrafish project. About a year has passed since they seriously started focusing on the potential of this tiny four-centimetre-long fish, and the possibilities are hugely exciting.

Looks are deceiving

Leading global genetics laboratories are replacing research on human and animal populations with zebrafish due to several fascinating reasons, of which the most profound is probably that the zebrafish share large portions of its genome with mammals. For genetics researchers this may make a lot of sense, but most people battle to see any resemblance between a six-foot-tall rugby player or 600 kg buffalo and a small, nearly transparent fish. It is in the detail, the researchers say.

Fast, effective, and visible

“The complete genome sequence of the zebrafish is known, and as much as 84% of genes known to be associated with human disease have zebrafish counterparts,” explains Head of Department, Prof Paul Grobler. Another advantage is the fast breeding rate and short generation time, and the fact that some research is ethically more justifiable when done on fish larvae rather than on adult mammals. The fact that zebrafish embryos are virtually transparent, also allow researchers to examine the development of internal structures without effort. Every blood vessel in a living zebrafish embryo is visible under a low-power microscope.

Multidisciplinary

Zebrafish provide research potential for many different study fields besides that of Prof Grobler and his team, Sue Rica Schneider and Dr Willem Coetzer. In the near future, they aim to have undergraduate students use zebrafish as a research model to develop a real sense of research and laboratory work. The Department of Chemistry are also initiating research on zebrafish housed in the Department of Genetics.

News Archive

Bright young mind shines
2016-12-12

Description:Candice Thikeson  Tags: Bowls  longdesc=


Candice Thikeson, a Master’s
student in Arts History and
Image Studies at the University
of the Free State.
Photo: Anja Aucamp

“I was once told that I looked ‘immaculate’, as always. We use the word ‘immaculate’ to describe the Virgin Mary, does it get better than that?”

To everyone else, she may be a Mandela Rhodes Scholar, Bright Young Mind and Abe Bailey Travel Bursary candidate, but there is more to this beauty that meets the eye.

Relating to women in the humanities field

Candice Thikeson, who is currently a Master’s student in Art History and Image Studies, says “I have a very strong spiritual foundation and my relationship with God really fuels everything I do. I also think being intentional about building great relationships with your family and friends is imperative.”

She says she has been inspired by different people at different stages of her life and draws a great deal from academics, creatives and activists. She relates best to women who are in the humanities and draws inspiration from the likes of Nigerian novelist, Chimamanda Ngozi Adichie, and Kenya-born, Somalian poet Warsan Shire.

“I love how they are able to comment on some of the most pressing issues black women face through beautiful and poignant writing. I also admire how frank these women are, something I’m still learning to be,” Thikeson says.

Pursue something you are genuinely interested in

The biggest misconception people have of her is that she studies art and she is working towards becoming an artist. “Fine art and art history is not the same thing. I don’t paint or make art at university, and I really don’t enjoy being called an artist.”

When asked about how she has become so successful at such a young age, she reiterated the cliché: “pursue something you are genuinely interested in and passionate about”. She adds, “if you are really good at what you do, your gift will make room for you in your field”.

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