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24 December 2018 | Story Leonie Bolleurs | Photo Anja Aucamp
Research possibilities of zebrafish exposed
Leading global genetics laboratories are replacing research on human and animal populations with zebrafish, says Prof Paul Grobler, Head of the UFS Department of Genetics.

The UFS Department of Genetics is on par with current research trends in terms of their zebrafish project. About a year has passed since they seriously started focusing on the potential of this tiny four-centimetre-long fish, and the possibilities are hugely exciting.

Looks are deceiving

Leading global genetics laboratories are replacing research on human and animal populations with zebrafish due to several fascinating reasons, of which the most profound is probably that the zebrafish share large portions of its genome with mammals. For genetics researchers this may make a lot of sense, but most people battle to see any resemblance between a six-foot-tall rugby player or 600 kg buffalo and a small, nearly transparent fish. It is in the detail, the researchers say.

Fast, effective, and visible

“The complete genome sequence of the zebrafish is known, and as much as 84% of genes known to be associated with human disease have zebrafish counterparts,” explains Head of Department, Prof Paul Grobler. Another advantage is the fast breeding rate and short generation time, and the fact that some research is ethically more justifiable when done on fish larvae rather than on adult mammals. The fact that zebrafish embryos are virtually transparent, also allow researchers to examine the development of internal structures without effort. Every blood vessel in a living zebrafish embryo is visible under a low-power microscope.

Multidisciplinary

Zebrafish provide research potential for many different study fields besides that of Prof Grobler and his team, Sue Rica Schneider and Dr Willem Coetzer. In the near future, they aim to have undergraduate students use zebrafish as a research model to develop a real sense of research and laboratory work. The Department of Chemistry are also initiating research on zebrafish housed in the Department of Genetics.

News Archive

Prof. Dingie Janse van Rensburg promoted to Outstanding Professor
2007-11-19

The University of the Free State (UFS) is pleased to announce that Prof. Dingie Janse van Rensburg, Director of the Centre for Health Systems Research and Development has been promoted to Outstanding Professor.

In 1991 the Executive Committee of the Council introduced the category of Outstanding Professor to give recognition to a small group of outstanding academics. Not many academics at the UFS received this status since then.

Prof. Janse van Rensburg has been working at the UFS for 37 years and played a big role in establishing a culture of scientific publication among young and upcoming researchers.

Prof. Janse van Rensburg enjoys extensive national and international recognition as researcher and research manager. He delivered various national and international papers and is involved in a variety of international research projects – some of which were initiated by him. He succeeded in involving a variety of foreign researchers in long term research projects.

In 1993 he established an entrepreneurial research and development centre, which he has sustained for more than 13 years. The centre enjoys recognition nationally as well as internationally as well as credibility in the eyes of the international donor community, within government’s health sphere as well as in peer academic circles.

Prof. Janse van Rensburg has for several years been a grant holder of both the National Research Foundation and the Medical Research Council for research projects on Tuberculosis and HIV/Aids.

During his career at the UFS Prof. Janse van Rensburg received several merit awards and commendations from the UFS and other institutions. These include the Stals Prize in 1993 from the Suid-Afrikaanse Akademie vir Wetenskap en Kuns, a Council Medal from the UFS in 2003, the UFS Centenary Medal in 2004, an award from the Department of Health in 2004 for excellence and continued support of this department, a promotion to Senior Professor from the UFS in 2005 and the Free State Premier’s Excellence Award Gold category in 2006 for excellence in research and development.

Media Release
Issued by: Lacea Loader
Assistant Director: Media Liaison
Tel: 051 401 2584
Cell: 083 645 2454
E-mail: loaderl.stg@ufs.ac.za  
19 November 2007
 

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