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07 January 2018 Photo Charl Devenish
Researcher tackling drug-resistant TB through molecular methods
Dr Anneke van der Spoel van Dijk is invested in contributing to the global effort of stopping TB by 2035.

The work of Dr Anneke van der Spoel van Dijk investigates the spread of TB in the Free State population using techniques such as next generation sequencing, spoligotyping and MIRU-VNTR typing. Dr Van der Spoel van Dijk, a senior medical scientist in the Department of Medical Microbiology at the University of the Free State (UFS) also looks at drug resistance in her research. This work informs decisions about how best to treat patients with multidrug-resistant TB (MDR-TB). 

She employs rapid molecular techniques to track one of Africa’s most serious diseases, tuberculosis (TB). 

Drug resistance
Scientists assist the National Health Laboratory Service and Department of Health in trying to refine the diagnostic tools to identify these cases earlier. Dr Van der Spoel van Dijk explains: “Until recently, it took up to two years to fine-tune treatment decisions for patients with MDR-TB. Patients get a cocktail of anti-TB drugs, but it takes time to find the right combination. Re-infection and relapse (patients stopping treatment for several reasons) add to the diagnostic and treatment management challenges.

Enormous impact
“Now doctors can reduce the time needed for diagnostic certainty to about seven days, while new drugs allow reduction of treatment from more than 18 to nine months. This can have an enormous impact on the life of many patients.”

Dr Van der Spoel van Dijk’s work forms part of research in the faculty looking at resistance development in TB strains. She is currently also doing her doctoral thesis on the differences and incidence of MDR-TB among adolescents versus adults. Dr Van der Spoel van Dijk says: “It is a complicated picture, but we hope to unravel it to support better diagnostic tools and patient care.”

As part of the National Health Laboratory Service, her department is playing an important role in TB diagnostics and the training of scientists and future pathologists. “Our work is contributing to the global vision to stop TB by 2035,” Dr Van der Spoel van Dijk says.

News Archive

UFS-NSTF winners to make presentations
2008-07-21

Staff members of the University of the Free State (UFS) who are recent winners of two prestigious National Science and Technology Forum (NSTF) awards will make presentations at the CR Swart Building on the Main Campus in Bloemfontein on 31 July 2008.

Prof Maryke Labuschagne from the Department of Plant Sciences will present a paper on “The importance of training in agriculture in Africa”. She received an award for the development of research capacity over the last ten years. She is an expert in the field of plant breeding and food security in Africa and was rewarded for her outstanding contribution to the development and training of black researchers and students.

The recipients of the other award, Prof Jan van der Westhuizen from the Department of Chemistry and Prof Kenneth Swart from FARMOVS-PAREXEL, will present a paper on “Bio-analytical chemistry”. Both are members of a team that also includes Dr Susan Bonnet from the Chemistry Department and Prof Thinus van der Merwe from FARMOVS-PAREXEL, and which received the award for innovation and outstanding contribution to science, engineering and technology by either an individual or a team over the last ten years.

The presentations will start at 11:00.

Media Release
Issued by: Mangaliso Radebe
Assistant Director: Media Liaison
Tel: 051 401 2828
Cell: 078 460 3320
E-mail: radebemt.stg@ufs.ac.za  
21 July 2008

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