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07 January 2018 Photo Charl Devenish
Researcher tackling drug-resistant TB through molecular methods
Dr Anneke van der Spoel van Dijk is invested in contributing to the global effort of stopping TB by 2035.

The work of Dr Anneke van der Spoel van Dijk investigates the spread of TB in the Free State population using techniques such as next generation sequencing, spoligotyping and MIRU-VNTR typing. Dr Van der Spoel van Dijk, a senior medical scientist in the Department of Medical Microbiology at the University of the Free State (UFS) also looks at drug resistance in her research. This work informs decisions about how best to treat patients with multidrug-resistant TB (MDR-TB). 

She employs rapid molecular techniques to track one of Africa’s most serious diseases, tuberculosis (TB). 

Drug resistance
Scientists assist the National Health Laboratory Service and Department of Health in trying to refine the diagnostic tools to identify these cases earlier. Dr Van der Spoel van Dijk explains: “Until recently, it took up to two years to fine-tune treatment decisions for patients with MDR-TB. Patients get a cocktail of anti-TB drugs, but it takes time to find the right combination. Re-infection and relapse (patients stopping treatment for several reasons) add to the diagnostic and treatment management challenges.

Enormous impact
“Now doctors can reduce the time needed for diagnostic certainty to about seven days, while new drugs allow reduction of treatment from more than 18 to nine months. This can have an enormous impact on the life of many patients.”

Dr Van der Spoel van Dijk’s work forms part of research in the faculty looking at resistance development in TB strains. She is currently also doing her doctoral thesis on the differences and incidence of MDR-TB among adolescents versus adults. Dr Van der Spoel van Dijk says: “It is a complicated picture, but we hope to unravel it to support better diagnostic tools and patient care.”

As part of the National Health Laboratory Service, her department is playing an important role in TB diagnostics and the training of scientists and future pathologists. “Our work is contributing to the global vision to stop TB by 2035,” Dr Van der Spoel van Dijk says.

News Archive

New book recommends “rethinking of university readiness”
2015-06-01

A young man draws himself standing behind a brick wall in darkness, striving in vain to reach success and sunshine on the other side. This drawing aptly illustrates the focus of Dr Merridy Wilson-Strydom’s book University Access and Success: Capabilities, diversity and social justice.

Using the capabilities approach, Dr Wilson-Strydom considers the individual wellbeing and quality of life of students as central metrics for understanding access and success. Based on a combination of quantitative and qualitative research, including focus groups, written reflections and drawings, interviews, and participatory workshops, she identifies seven key capabilities needed for a student to successfully transition to university life, namely:

  1. Practical reason
  2. Knowledge and imagination
  3. Learning disposition
  4. Social relations and social networks
  5. Respect, dignity and recognition
  6. Emotional health
  7. Language competence and confidence

At the launch of the book at the UFS recently, Prof Sandra Boni, from the Universidad Politécnica de Valencia in Spain, said: “From a methodological perspective, this book is an excellent contribution in the educational research domain ... It brings a richness of data that allows the author to explore in a deeper way the personal characteristics and the social factors that influence the capability [of students] to participate. ... This book offers interesting avenues for action in the university realm.”

Dr Lis Lange, Vice-Rector: Academic at the UFS, said at the same event: “We will have to rethink what we are doing and how we are doing it. I would like to make it prescribed reading for all deans and HODs.”

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