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07 January 2018 Photo Charl Devenish
Researcher tackling drug-resistant TB through molecular methods
Dr Anneke van der Spoel van Dijk is invested in contributing to the global effort of stopping TB by 2035.

The work of Dr Anneke van der Spoel van Dijk investigates the spread of TB in the Free State population using techniques such as next generation sequencing, spoligotyping and MIRU-VNTR typing. Dr Van der Spoel van Dijk, a senior medical scientist in the Department of Medical Microbiology at the University of the Free State (UFS) also looks at drug resistance in her research. This work informs decisions about how best to treat patients with multidrug-resistant TB (MDR-TB). 

She employs rapid molecular techniques to track one of Africa’s most serious diseases, tuberculosis (TB). 

Drug resistance
Scientists assist the National Health Laboratory Service and Department of Health in trying to refine the diagnostic tools to identify these cases earlier. Dr Van der Spoel van Dijk explains: “Until recently, it took up to two years to fine-tune treatment decisions for patients with MDR-TB. Patients get a cocktail of anti-TB drugs, but it takes time to find the right combination. Re-infection and relapse (patients stopping treatment for several reasons) add to the diagnostic and treatment management challenges.

Enormous impact
“Now doctors can reduce the time needed for diagnostic certainty to about seven days, while new drugs allow reduction of treatment from more than 18 to nine months. This can have an enormous impact on the life of many patients.”

Dr Van der Spoel van Dijk’s work forms part of research in the faculty looking at resistance development in TB strains. She is currently also doing her doctoral thesis on the differences and incidence of MDR-TB among adolescents versus adults. Dr Van der Spoel van Dijk says: “It is a complicated picture, but we hope to unravel it to support better diagnostic tools and patient care.”

As part of the National Health Laboratory Service, her department is playing an important role in TB diagnostics and the training of scientists and future pathologists. “Our work is contributing to the global vision to stop TB by 2035,” Dr Van der Spoel van Dijk says.

News Archive

UFS celebrates establishment of a new department
2008-09-26

 

 At the celebration of the establishment of the Department of Genetics are, from the left: Prof. Herman van Schalkwyk, Dean: Faculty of Natural and Agricultural Sciences at the UFS, Prof. Johan Spies, head of the Department of Genetics at the UFS, Prof. Chris Viljoen, associate professor at the UFS Department of Haematology and Cell Biology and previously associated with the Department of Genetics; seated: Prof. Paul Grobler, associate professor at the UFS Department of Genetics.
Photo: Stephen Collett

UFS celebrates establishment of a new department

The establishment of the Department of Genetics in the Faculty of Natural and Agricultural Sciences at the University of the Free State (FS) was recently celebrated on the Main Campus in Bloemfontein.

The department, which formed part of the Department of Plant Sciences, is the only of its kind in the country that conducts research in behavioural genetics. “With behavioural genetics we try to determine if certain human behaviour is hereditary or if it is as a result of the environment. Although this is the fastest growing field of specialty in the United States of America, it is still an unknown field in South Africa,” says Prof. Johan Spies, head of the Department of Genetics.

The other specialty fields of the department are forensic genetics and conservation genetics. “Forensic genetics looks at the compilation of the DNA of animals. Because of our academics’ expertise, the department is regularly requested by the South African Police Service to assist them with establishing the origin of animals – especially in the case of game poaching. We recently completed a research project on cheetahs where we had to establish if they were acquired illegally of part of the farmer’s game. The research showed that the cheetahs were part of the farmer’s own breed,” says Prof. Spies.

Another specialty field of the department is conservation genetics where the genetic variance of animals is researched. A lot of research is done on vervet monkeys to determine from which area in the country they originate. The study must be completed before the 3000 vervet monkeys currently in rehabilitation centres are set free. The behaviour of monkeys in rehabilitation is also being researched.

Prof. Spies says: “Student figures in Genetics show an annual increase of 8% per year for the past five years. The first group of master’s degree students in Genetics will start their studies next year.” The department is also regarded as a leader on Clivia research.


Media Release
Issued by: Lacea Loader
Assistant Director: Media Liaison
Tel: 051 401 2584
Cell: 083 645 2454
E-mail: loaderl.stg@ufs.ac.za
25 September 2008
 

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