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07 January 2018 Photo Charl Devenish
Researcher tackling drug-resistant TB through molecular methods
Dr Anneke van der Spoel van Dijk is invested in contributing to the global effort of stopping TB by 2035.

The work of Dr Anneke van der Spoel van Dijk investigates the spread of TB in the Free State population using techniques such as next generation sequencing, spoligotyping and MIRU-VNTR typing. Dr Van der Spoel van Dijk, a senior medical scientist in the Department of Medical Microbiology at the University of the Free State (UFS) also looks at drug resistance in her research. This work informs decisions about how best to treat patients with multidrug-resistant TB (MDR-TB). 

She employs rapid molecular techniques to track one of Africa’s most serious diseases, tuberculosis (TB). 

Drug resistance
Scientists assist the National Health Laboratory Service and Department of Health in trying to refine the diagnostic tools to identify these cases earlier. Dr Van der Spoel van Dijk explains: “Until recently, it took up to two years to fine-tune treatment decisions for patients with MDR-TB. Patients get a cocktail of anti-TB drugs, but it takes time to find the right combination. Re-infection and relapse (patients stopping treatment for several reasons) add to the diagnostic and treatment management challenges.

Enormous impact
“Now doctors can reduce the time needed for diagnostic certainty to about seven days, while new drugs allow reduction of treatment from more than 18 to nine months. This can have an enormous impact on the life of many patients.”

Dr Van der Spoel van Dijk’s work forms part of research in the faculty looking at resistance development in TB strains. She is currently also doing her doctoral thesis on the differences and incidence of MDR-TB among adolescents versus adults. Dr Van der Spoel van Dijk says: “It is a complicated picture, but we hope to unravel it to support better diagnostic tools and patient care.”

As part of the National Health Laboratory Service, her department is playing an important role in TB diagnostics and the training of scientists and future pathologists. “Our work is contributing to the global vision to stop TB by 2035,” Dr Van der Spoel van Dijk says.

News Archive

UFS to celebrate Darwin Year
2008-11-10

The University of the Free State (UFS) will next year be celebrating Darwin Year with a comprehensive programme in which many of its departments will take part. The programme is spearheaded by the Faculty of Natural and Agricultural Sciences, in cooperation with the National Museum.

“Next year it will be 200 years since the birth of Charles Darwin and 150 years after the publication of the first edition of his famous book ‘On the Origin of Species’”, says Prof. Jo van As, chairperson of the organising committee and head of the Department of Zoology and Entomology at the UFS.

“The programme aims to portray the influence of Darwin’s theory of evolution on various fields in the natural and agricultural sciences. It will start in February 2009 and end a year later in February 2010. We see this as a good opportunity to promote science in its broadest context,” says Prof. Van As.

According to Prof. Van As a scientific lecture programme on evolution and its impact on various fields will be presented on the Main Campus of the UFS in Bloemfontein on a monthly basis throughout next year. These will include topics such as the mechanisms of evolution: heredity and natural selection, extinction, the start of agriculture, human demography, human impact and the resistance to HIV/Aids antibiotics. The theme of the lecture programme is “The Story of Life”.

A stage play to commemorate the life of Darwin and celebrate his contribution to the understanding of life will also be performed during the Volksblad-kunstefees.

The National Museum will host different events and exhibits. “They will participate in the programme presented at the UFS, present temporary exhibitions to coincide with the programme on campus and also present their own events,” says Prof. Van As.

More information about the programme can be obtained from Ms Isabel Human at 051 401 2427 or humanci.rd@ufs.ac.za.


Media Release
Issued by: Lacea Loader
Assistant Director: Media Liaison
Tel: 051 401 2584
Cell: 083 645 2454
E-mail: loaderl.stg@ufs.ac.za  
10 November 2008
 

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