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07 January 2018 Photo Charl Devenish
Researcher tackling drug-resistant TB through molecular methods
Dr Anneke van der Spoel van Dijk is invested in contributing to the global effort of stopping TB by 2035.

The work of Dr Anneke van der Spoel van Dijk investigates the spread of TB in the Free State population using techniques such as next generation sequencing, spoligotyping and MIRU-VNTR typing. Dr Van der Spoel van Dijk, a senior medical scientist in the Department of Medical Microbiology at the University of the Free State (UFS) also looks at drug resistance in her research. This work informs decisions about how best to treat patients with multidrug-resistant TB (MDR-TB). 

She employs rapid molecular techniques to track one of Africa’s most serious diseases, tuberculosis (TB). 

Drug resistance
Scientists assist the National Health Laboratory Service and Department of Health in trying to refine the diagnostic tools to identify these cases earlier. Dr Van der Spoel van Dijk explains: “Until recently, it took up to two years to fine-tune treatment decisions for patients with MDR-TB. Patients get a cocktail of anti-TB drugs, but it takes time to find the right combination. Re-infection and relapse (patients stopping treatment for several reasons) add to the diagnostic and treatment management challenges.

Enormous impact
“Now doctors can reduce the time needed for diagnostic certainty to about seven days, while new drugs allow reduction of treatment from more than 18 to nine months. This can have an enormous impact on the life of many patients.”

Dr Van der Spoel van Dijk’s work forms part of research in the faculty looking at resistance development in TB strains. She is currently also doing her doctoral thesis on the differences and incidence of MDR-TB among adolescents versus adults. Dr Van der Spoel van Dijk says: “It is a complicated picture, but we hope to unravel it to support better diagnostic tools and patient care.”

As part of the National Health Laboratory Service, her department is playing an important role in TB diagnostics and the training of scientists and future pathologists. “Our work is contributing to the global vision to stop TB by 2035,” Dr Van der Spoel van Dijk says.

News Archive

Academic appointed as Visiting Professor in the USA
2009-02-03

 

The Director of Research Development and Professor at the Centre for Sustainable Agriculture and Rural Development at the University of the Free State (UFS), Prof. Frans Swanepoel (pictured), has been appointed as Visiting Professor at Cornell University, New York, USA. He has just completed a five-month appointment as a Fulbright Professor at Cornell University. He and Cornell colleagues are collaborating on an initiative to revise agricultural education curricula in Africa, supported by the WK Kellogg and Bill and Melinda Gates Foundations. They are also working on a book, The Role of Livestock in Developing Communities: Enhancing Multifunctionality, to be published in June this year. He has also investigated best practice and latest developments in research management and innovation at a number of US universities and delivered the main paper by invitation at a workshop on Research Management at Emerging Institutions at the Society for Research Administrators’ Annual Conference in Washington DC in October last year. Cornell is the only Ivy League University in the USA with a College of Agriculture and Life Sciences.
Photo: Supplied

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