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07 January 2018 Photo Charl Devenish
Researcher tackling drug-resistant TB through molecular methods
Dr Anneke van der Spoel van Dijk is invested in contributing to the global effort of stopping TB by 2035.

The work of Dr Anneke van der Spoel van Dijk investigates the spread of TB in the Free State population using techniques such as next generation sequencing, spoligotyping and MIRU-VNTR typing. Dr Van der Spoel van Dijk, a senior medical scientist in the Department of Medical Microbiology at the University of the Free State (UFS) also looks at drug resistance in her research. This work informs decisions about how best to treat patients with multidrug-resistant TB (MDR-TB). 

She employs rapid molecular techniques to track one of Africa’s most serious diseases, tuberculosis (TB). 

Drug resistance
Scientists assist the National Health Laboratory Service and Department of Health in trying to refine the diagnostic tools to identify these cases earlier. Dr Van der Spoel van Dijk explains: “Until recently, it took up to two years to fine-tune treatment decisions for patients with MDR-TB. Patients get a cocktail of anti-TB drugs, but it takes time to find the right combination. Re-infection and relapse (patients stopping treatment for several reasons) add to the diagnostic and treatment management challenges.

Enormous impact
“Now doctors can reduce the time needed for diagnostic certainty to about seven days, while new drugs allow reduction of treatment from more than 18 to nine months. This can have an enormous impact on the life of many patients.”

Dr Van der Spoel van Dijk’s work forms part of research in the faculty looking at resistance development in TB strains. She is currently also doing her doctoral thesis on the differences and incidence of MDR-TB among adolescents versus adults. Dr Van der Spoel van Dijk says: “It is a complicated picture, but we hope to unravel it to support better diagnostic tools and patient care.”

As part of the National Health Laboratory Service, her department is playing an important role in TB diagnostics and the training of scientists and future pathologists. “Our work is contributing to the global vision to stop TB by 2035,” Dr Van der Spoel van Dijk says.

News Archive

"We cannot train for unemployment"
2009-11-16

The prestige forum was attended by, from the left: Prof. Dirk van Damme, Head of the Centre for Education research and innovation at OECD in Paris, France; Dr Saretha Brüssow of the Planning Unit: Teaching and Learning; Mr Francois Marais, Director of CHESD; Prof. Jonathan Jansen, Rector and Vice-Chancellor; Prof. Driekie Hay, Vice-Rector Academic Planning and the guest speaker; and Prof. Magda Fourie of the University of Stellenbosch.
Photo: Gerhard Louw
“We cannot train for unemployment. We must continuously look at what employers and the world want, and update,” Prof. Magda Fourie, Vice-Rector: Teaching and Learning at the University of Stellenbosch, recently said at a prestige forum for teaching and learning at the University of the Free State (UFS).

Prof. Fourie, former Vice-Rector: Academic Planning at the UFS delivered the second Magda Fourie Prestige Lecture at the forum. The forum was presented by the Centre for Higher Education Studies and Learning (CHESD) and the Planning Unit: Teaching and Learning. Various presentations were made on innovations in teaching and learning at the UFS.

Prof. Fourie said research has shown that the knowledge, skills, competencies and values of students are out of sync with the needs of the world out there. Higher Education must look at the context in which it operates and the relevance of its teaching and learning. “We are busy with the cultivation of humanity,” she said.

The UFS is doing excellent work with its bridging programmes and other universities will have to give attention to it. The UFS is also excellent in its extended programmes and have more women and foreign students than the national average. The UFS, however, has a lower percentage of black students than the national average.

The UFS is also excellent in terms of postgraduate students. The national average is 36%, with the UFS boasting 47%. Prof. Fourie expressed her concern for the low throughput in Business and Economics at the UFS where only 13% of those who enter the system graduate. “These are the people we need for this country’s economy.”

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