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Researcher tackling drug-resistant TB through molecular methods
Dr Anneke van der Spoel van Dijk is invested in contributing to the global effort of stopping TB by 2035.

The work of Dr Anneke van der Spoel van Dijk investigates the spread of TB in the Free State population using techniques such as next generation sequencing, spoligotyping and MIRU-VNTR typing. Dr Van der Spoel van Dijk, a senior medical scientist in the Department of Medical Microbiology at the University of the Free State (UFS) also looks at drug resistance in her research. This work informs decisions about how best to treat patients with multidrug-resistant TB (MDR-TB). 

She employs rapid molecular techniques to track one of Africa’s most serious diseases, tuberculosis (TB). 

Drug resistance
Scientists assist the National Health Laboratory Service and Department of Health in trying to refine the diagnostic tools to identify these cases earlier. Dr Van der Spoel van Dijk explains: “Until recently, it took up to two years to fine-tune treatment decisions for patients with MDR-TB. Patients get a cocktail of anti-TB drugs, but it takes time to find the right combination. Re-infection and relapse (patients stopping treatment for several reasons) add to the diagnostic and treatment management challenges.

Enormous impact
“Now doctors can reduce the time needed for diagnostic certainty to about seven days, while new drugs allow reduction of treatment from more than 18 to nine months. This can have an enormous impact on the life of many patients.”

Dr Van der Spoel van Dijk’s work forms part of research in the faculty looking at resistance development in TB strains. She is currently also doing her doctoral thesis on the differences and incidence of MDR-TB among adolescents versus adults. Dr Van der Spoel van Dijk says: “It is a complicated picture, but we hope to unravel it to support better diagnostic tools and patient care.”

As part of the National Health Laboratory Service, her department is playing an important role in TB diagnostics and the training of scientists and future pathologists. “Our work is contributing to the global vision to stop TB by 2035,” Dr Van der Spoel van Dijk says.

News Archive

UFS will increase its volume of quality research
2009-11-25

 
From the left are, seated: Prof. Alice Pell, Vice-Provost: International Relations at Cornell University in the USA and Prof. Jonathan Jansen, Rector and Vice-Chancellor of the UFS; standing: Prof. Ezekiel Moraka, Vice-Rector: External Relations at the UFS, and Prof. David Wolfe from Cornell University during the signing of a memorandum of agreement between the two institutions.
Photo: Stephen Collett

The University of the Free State (UFS) is taking its research serious and is therefore going to increase its volume of quality research. This includes the production of quality scholarly books in the humanities and social sciences.

This was said by Prof. Jonathan Jansen, Rector and Vice-Chancellor, at the launch of the Strategic Academic Cluster initiative of the University on the Main Campus in Bloemfontein last night.

“We are going to produce the kind of research that is associated with scholarships. New models of training, new standards of performance and the introduction of an accelerated Vice-Chancellor’s Prestige Scholars’ Programme are among the initiatives that will be introduced. These are all aimed at boosting our university’s research performance,” said Prof. Jansen.

Another strategy to boost research performance at the UFS is the search for 25 leading professors to be appointed across the disciplines, but especially in the social sciences, education and the humanities. These positions have already been advertised and will be phased in with the goal of achieving equity and excellence in the academic and research profile of the UFS. “We’ve had an overwhelming response to the advertisements from local academics as well as those abroad,” said Prof. Jansen.

Each of the six Cluster Directors gave a short presentation of its aim and focus areas during last night’s dinner. These Clusters will in future direct the University’s research endeavours. It represents a move from a fragmented to a more focused approach to research development at the UFS.

The UFS also signed a memorandum of agreement with Cornell University (USA) last night. The guest speaker, Prof. Alice Pell, Vice-Provost: International Relations at Cornell University and member of the UFS’s International Advisory Board, said that, just as the cluster research teams need representatives from different disciplines, universities need diverse partners to recognise their potential fully. Collaborating with partners with ‘fresh eyes’ that have different cultural perspectives, access to different technologies and partners with different priorities can have important implications in the research and education provided by the UFS and Cornell,” she said.

“The interdisciplinary approach adopted by the UFS in developing the Strategic Academic Clusters seems likely to provide students with the intellectual frameworks and research tools that they need to address the problems in society,” she said.

“The most important issues facing the USA and South Africa are similar, namely how to effect the social transformation that will provide equal opportunities to all of our citizens. South Africa, Brazil, India and the USA share strong commitments to democracy, to overcoming our dark histories of religious and racial discrimination and to sustainable economic development without adverse impacts on our planet. We at Cornell are excited about the opportunity to work with the UFS on all of the clusters, but we are particularly looking forward to learning more about social transformation,” said Prof. Pell.

Media release
Issued by: Lacea Loader
Deputy Director: Media Liaison
Tel: 051 401 2584
Cell: 083 645 2454
E-mail: loaderl.stg@ufs.ac.za  
24 November 2009

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