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07 January 2018 Photo Charl Devenish
Researcher tackling drug-resistant TB through molecular methods
Dr Anneke van der Spoel van Dijk is invested in contributing to the global effort of stopping TB by 2035.

The work of Dr Anneke van der Spoel van Dijk investigates the spread of TB in the Free State population using techniques such as next generation sequencing, spoligotyping and MIRU-VNTR typing. Dr Van der Spoel van Dijk, a senior medical scientist in the Department of Medical Microbiology at the University of the Free State (UFS) also looks at drug resistance in her research. This work informs decisions about how best to treat patients with multidrug-resistant TB (MDR-TB). 

She employs rapid molecular techniques to track one of Africa’s most serious diseases, tuberculosis (TB). 

Drug resistance
Scientists assist the National Health Laboratory Service and Department of Health in trying to refine the diagnostic tools to identify these cases earlier. Dr Van der Spoel van Dijk explains: “Until recently, it took up to two years to fine-tune treatment decisions for patients with MDR-TB. Patients get a cocktail of anti-TB drugs, but it takes time to find the right combination. Re-infection and relapse (patients stopping treatment for several reasons) add to the diagnostic and treatment management challenges.

Enormous impact
“Now doctors can reduce the time needed for diagnostic certainty to about seven days, while new drugs allow reduction of treatment from more than 18 to nine months. This can have an enormous impact on the life of many patients.”

Dr Van der Spoel van Dijk’s work forms part of research in the faculty looking at resistance development in TB strains. She is currently also doing her doctoral thesis on the differences and incidence of MDR-TB among adolescents versus adults. Dr Van der Spoel van Dijk says: “It is a complicated picture, but we hope to unravel it to support better diagnostic tools and patient care.”

As part of the National Health Laboratory Service, her department is playing an important role in TB diagnostics and the training of scientists and future pathologists. “Our work is contributing to the global vision to stop TB by 2035,” Dr Van der Spoel van Dijk says.

News Archive

Research at the UFS on the acceptability and modern use of earth building in newly settled urban areas can help the poorest of the poor to acquire hou
2003-08-26

The University of the Free State and the Technische Universiteit van Eindhoven in the Netherlands received a research bursary of R316 000 from SANPAD (South African Netherlands Research Programme on Alternatives in Development).

The aim of the research is to determine the public acceptability of sustainable, high quality, earth constructed public and private buildings as an alternative to the conventional way of building with bricks and steel.

“European countries like the Netherlands are far advanced with studies in earth construction and this is why the partnership was formed with the Technische Universiteit van Eindhoven,” says Prof Das Steÿn, Head of Urban and Regional Planning at the UFS and project leader.

Although research regarding mapping, typology and availability of natural and local resources has been done on a national level, little research has been done on the acceptability and the modern use of earth building in newly settled urban areas.

“South Africa has a large housing shortage and traditional methods such as earth building techniques are not used in urban informal housing. Preference is given to corrugated iron sheets and plastic,” says Prof Steÿn.

The use of upgraded earth construction might be more sustainable as far as the environment and the economy is concerned. “If we can make a breakthrough in the development and propagating of these methods it will help the poorest of the poor to acquire housing of a better quality.”

The research team from the UFS consists of Prof Steÿn, Ms Petria Jooste-Smit, Head of the Unit for Earth Construction in the Department of Architecture and Mr Gerhard Bosman of the Department of Architecture.
 

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