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07 January 2018 Photo Charl Devenish
Researcher tackling drug-resistant TB through molecular methods
Dr Anneke van der Spoel van Dijk is invested in contributing to the global effort of stopping TB by 2035.

The work of Dr Anneke van der Spoel van Dijk investigates the spread of TB in the Free State population using techniques such as next generation sequencing, spoligotyping and MIRU-VNTR typing. Dr Van der Spoel van Dijk, a senior medical scientist in the Department of Medical Microbiology at the University of the Free State (UFS) also looks at drug resistance in her research. This work informs decisions about how best to treat patients with multidrug-resistant TB (MDR-TB). 

She employs rapid molecular techniques to track one of Africa’s most serious diseases, tuberculosis (TB). 

Drug resistance
Scientists assist the National Health Laboratory Service and Department of Health in trying to refine the diagnostic tools to identify these cases earlier. Dr Van der Spoel van Dijk explains: “Until recently, it took up to two years to fine-tune treatment decisions for patients with MDR-TB. Patients get a cocktail of anti-TB drugs, but it takes time to find the right combination. Re-infection and relapse (patients stopping treatment for several reasons) add to the diagnostic and treatment management challenges.

Enormous impact
“Now doctors can reduce the time needed for diagnostic certainty to about seven days, while new drugs allow reduction of treatment from more than 18 to nine months. This can have an enormous impact on the life of many patients.”

Dr Van der Spoel van Dijk’s work forms part of research in the faculty looking at resistance development in TB strains. She is currently also doing her doctoral thesis on the differences and incidence of MDR-TB among adolescents versus adults. Dr Van der Spoel van Dijk says: “It is a complicated picture, but we hope to unravel it to support better diagnostic tools and patient care.”

As part of the National Health Laboratory Service, her department is playing an important role in TB diagnostics and the training of scientists and future pathologists. “Our work is contributing to the global vision to stop TB by 2035,” Dr Van der Spoel van Dijk says.

News Archive

UFS partners with the Steve Biko Foundation
2010-09-14

The Steve Biko Foundation, with the support of the University of the Free State (UFS) and other stakeholders, recently presented the Annual Steve Biko Memorial Lecture as part of the 33rd Anniversary Commemoration of Steve Biko at the University of Cape Town. The lecture, Coming to See You Since I was Five Years Old: An American poet's connection to the South African soul, was delivered by Pulitzer Prize winner Prof. Alice Walker. She drew on her poetry, personal history and the inspirational role of the South African liberation struggle to disenfranchised people around the world.

This prestigious lecture has to date been delivered by, amongst others, such luminaries as former presidents Nelson Mandela and Thabo Mbeki, Archbishop Desmond Tutu and Prof. Chinua Achebe. The lecture was preceded by an evening of poetry and prose, An evening with Alice Walker, at the State Theatre in Pretoria where the UFS was also represented. Pictured at the lecture are the UFS representatives, from the left: Mr Teboho Manchu (Director: Student Affairs, Qwaqwa Campus), Mr Willem Ellis (Centre for Development Support), Ms Lihlomelo Toyana (student), Mr JC van der Merwe (Department of Philosophy) and Mr Billyboy Ramahlele (Director: Community Engagement).
Photo: Mangaliso Radebe

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