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07 January 2018 Photo Charl Devenish
Researcher tackling drug-resistant TB through molecular methods
Dr Anneke van der Spoel van Dijk is invested in contributing to the global effort of stopping TB by 2035.

The work of Dr Anneke van der Spoel van Dijk investigates the spread of TB in the Free State population using techniques such as next generation sequencing, spoligotyping and MIRU-VNTR typing. Dr Van der Spoel van Dijk, a senior medical scientist in the Department of Medical Microbiology at the University of the Free State (UFS) also looks at drug resistance in her research. This work informs decisions about how best to treat patients with multidrug-resistant TB (MDR-TB). 

She employs rapid molecular techniques to track one of Africa’s most serious diseases, tuberculosis (TB). 

Drug resistance
Scientists assist the National Health Laboratory Service and Department of Health in trying to refine the diagnostic tools to identify these cases earlier. Dr Van der Spoel van Dijk explains: “Until recently, it took up to two years to fine-tune treatment decisions for patients with MDR-TB. Patients get a cocktail of anti-TB drugs, but it takes time to find the right combination. Re-infection and relapse (patients stopping treatment for several reasons) add to the diagnostic and treatment management challenges.

Enormous impact
“Now doctors can reduce the time needed for diagnostic certainty to about seven days, while new drugs allow reduction of treatment from more than 18 to nine months. This can have an enormous impact on the life of many patients.”

Dr Van der Spoel van Dijk’s work forms part of research in the faculty looking at resistance development in TB strains. She is currently also doing her doctoral thesis on the differences and incidence of MDR-TB among adolescents versus adults. Dr Van der Spoel van Dijk says: “It is a complicated picture, but we hope to unravel it to support better diagnostic tools and patient care.”

As part of the National Health Laboratory Service, her department is playing an important role in TB diagnostics and the training of scientists and future pathologists. “Our work is contributing to the global vision to stop TB by 2035,” Dr Van der Spoel van Dijk says.

News Archive

School of Medicine accredited
2005-05-18

The School of Medicine in the Faculty of Health Sciences at the University of the Free State (USF) is now one of only a handful of similar South African schools with a five year curriculum which received accreditation from the Health Profession Council of South Africa (HPCSA).

Prof. Gert van Zyl, Head of the school, said the school is very proud of this achievement. It means that the hard work of students and staff over the past few years are now being rewarded.

“This curriculum is similar to those of the world’s best medical schools. Most other South African medical schools are still following the six year curriculum. The UFS accreditation is applicable for the next five years.

“A special committee of the HPCSA requires a number of documents and a presentation on the quality and standard of teaching at the school.”

As a result of the five year curriculum students of the UFS medical school start working one year earlier than students of other universities. This lightens the burden of a year’s class fees.

“This accreditation is not voluntarily. If the school did not receive accreditation now, we would have to start the process again,” said Van Zyl. 

Michelé O'Connor, Volksblad, 13 May 2005

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