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07 January 2018 Photo Charl Devenish
Researcher tackling drug-resistant TB through molecular methods
Dr Anneke van der Spoel van Dijk is invested in contributing to the global effort of stopping TB by 2035.

The work of Dr Anneke van der Spoel van Dijk investigates the spread of TB in the Free State population using techniques such as next generation sequencing, spoligotyping and MIRU-VNTR typing. Dr Van der Spoel van Dijk, a senior medical scientist in the Department of Medical Microbiology at the University of the Free State (UFS) also looks at drug resistance in her research. This work informs decisions about how best to treat patients with multidrug-resistant TB (MDR-TB). 

She employs rapid molecular techniques to track one of Africa’s most serious diseases, tuberculosis (TB). 

Drug resistance
Scientists assist the National Health Laboratory Service and Department of Health in trying to refine the diagnostic tools to identify these cases earlier. Dr Van der Spoel van Dijk explains: “Until recently, it took up to two years to fine-tune treatment decisions for patients with MDR-TB. Patients get a cocktail of anti-TB drugs, but it takes time to find the right combination. Re-infection and relapse (patients stopping treatment for several reasons) add to the diagnostic and treatment management challenges.

Enormous impact
“Now doctors can reduce the time needed for diagnostic certainty to about seven days, while new drugs allow reduction of treatment from more than 18 to nine months. This can have an enormous impact on the life of many patients.”

Dr Van der Spoel van Dijk’s work forms part of research in the faculty looking at resistance development in TB strains. She is currently also doing her doctoral thesis on the differences and incidence of MDR-TB among adolescents versus adults. Dr Van der Spoel van Dijk says: “It is a complicated picture, but we hope to unravel it to support better diagnostic tools and patient care.”

As part of the National Health Laboratory Service, her department is playing an important role in TB diagnostics and the training of scientists and future pathologists. “Our work is contributing to the global vision to stop TB by 2035,” Dr Van der Spoel van Dijk says.

News Archive

Americans want to strengthen ties with UFS
2011-04-06

Representatives from our university and Wisconsin’s Milwaukee Campus (UWM) in America met about possible collaborative agreements during the past week. Here are, from the left: Profs. Hannes Britz, the Provost (Academic); Tien-Chien Jen, UWM Dean of the College of Engineering; and Wade Hobgood, Dean of the Peck School of Art. In front sits Dr Nalize Marais from the Directorate for Institutional Research and Academic Planning.


Photo: Gerda-Marie Viviers

Academics from the University of Wisconsin’s Milwaukee Campus (UWM) paid a visit to our university on 22 March 2011. The visit was earmarked to investigate possible research and collaborative agreements. Academic areas which were focused on prominently were engineering, water science, and education, specifically with regard to the disciplines of mathematics, science, technology and the arts. UFS lecturers representing the Faculties of Natural and Agricultural Sciences, Education and Health Sciences participated in the discussions. According to Dr Nalize Marais from the Directorate for Institutional Research and Academic Planning, possible agreements relate to exchange students, teaching opportunities for academic staff and joint research projects. “Personally, I am going to work with them (UWM) on programme planning and curriculum design for six weeks starting next week.'' She said that other UFS staff would probably also travel to Milwaukee later this year for amongst others research, new programmes and teaching.

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