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07 January 2018 Photo Charl Devenish
Researcher tackling drug-resistant TB through molecular methods
Dr Anneke van der Spoel van Dijk is invested in contributing to the global effort of stopping TB by 2035.

The work of Dr Anneke van der Spoel van Dijk investigates the spread of TB in the Free State population using techniques such as next generation sequencing, spoligotyping and MIRU-VNTR typing. Dr Van der Spoel van Dijk, a senior medical scientist in the Department of Medical Microbiology at the University of the Free State (UFS) also looks at drug resistance in her research. This work informs decisions about how best to treat patients with multidrug-resistant TB (MDR-TB). 

She employs rapid molecular techniques to track one of Africa’s most serious diseases, tuberculosis (TB). 

Drug resistance
Scientists assist the National Health Laboratory Service and Department of Health in trying to refine the diagnostic tools to identify these cases earlier. Dr Van der Spoel van Dijk explains: “Until recently, it took up to two years to fine-tune treatment decisions for patients with MDR-TB. Patients get a cocktail of anti-TB drugs, but it takes time to find the right combination. Re-infection and relapse (patients stopping treatment for several reasons) add to the diagnostic and treatment management challenges.

Enormous impact
“Now doctors can reduce the time needed for diagnostic certainty to about seven days, while new drugs allow reduction of treatment from more than 18 to nine months. This can have an enormous impact on the life of many patients.”

Dr Van der Spoel van Dijk’s work forms part of research in the faculty looking at resistance development in TB strains. She is currently also doing her doctoral thesis on the differences and incidence of MDR-TB among adolescents versus adults. Dr Van der Spoel van Dijk says: “It is a complicated picture, but we hope to unravel it to support better diagnostic tools and patient care.”

As part of the National Health Laboratory Service, her department is playing an important role in TB diagnostics and the training of scientists and future pathologists. “Our work is contributing to the global vision to stop TB by 2035,” Dr Van der Spoel van Dijk says.

News Archive

UFS outlines research achievements
2011-09-02

 

At the launch of the 2010 Annual Research Report, were from the left: Mr Robert Kriger, the director for Policy and Strategy at the National Research Foundation (NRF); Prof. Driekie Hay, Vice-Rector: Academic and Prof. Frans Swanepoel, Senior Director: Research Development.
Photo: Stephen Collett

The University of the Free State (UFS) is well on course for delivery on its most important academic duty as a research university. This was the message that came forward at the launch of the 2010 Annual Research Report of the UFS on 30 August 2011.

Speakers at the launch, which included Prof. Jonathan Jansen, Vice-Chancellor and Rector, as well as Prof. Driekie Hay, Vice-Rector: Academics outlined the key strategies and achievements of the UFS for the 2010 academic year. This included the establishment of a Postgraduate School at the UFS, the first of its kind at a public university in South Africa. Prof. Hay told guests that the aim of the Postgraduate School was to broaden research and deepens scholarship on postgraduate education in the country. She highlighted some initiatives the UFS undertook in 2010 to build and maintain its intellectual capital. Some of these initiatives included the appointment of seven senior professors and recruiting more female and black scholars and academics.   
Also speaking at the event was Mr Robert Kriger, the director for Policy and Strategy at the National Research Foundation (NRF). Kriger reflected on the brilliant minds of scholars such as Archie Mafeje, Lewis Nkosi and Dennis Brutus and argued for efforts to increase the country’s research output.
Some highlights of the 2010 Annual Research Report:
  • The total funding available for research at the UFS increased from approximately R199 million in 2009 to just over R210 million in 2010. A total of R31.8 million was made available from central university funds.
  • In 2010 the UFS was home to 92 NRF-rated researchers. During 2010, four researchers applied for re-evaluation and of these, two improved their rating, while a further five received a first-time rating.
  • The Faculty of Natural and Agricultural Sciences continue to be the most prolific producer of publications in accredited journals, while the Faculty of Education has shown a 54% increase in its publication output.
  • Staff members in the Physics department at the UFS Qwaqwa Campus published 22 papers in international peer-reviewed journals during 2010.
  • Also at the Qwaqwa Campus: Ms Khethiwe Mtshali,a postgraduate student in the parasitology research unit of the Department of Zoology and Entomology, received a best Honours presenter award at the 1st Annual Research symposium of the National Zoological Gardens of South Africa.

 

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