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07 January 2018 Photo Charl Devenish
Researcher tackling drug-resistant TB through molecular methods
Dr Anneke van der Spoel van Dijk is invested in contributing to the global effort of stopping TB by 2035.

The work of Dr Anneke van der Spoel van Dijk investigates the spread of TB in the Free State population using techniques such as next generation sequencing, spoligotyping and MIRU-VNTR typing. Dr Van der Spoel van Dijk, a senior medical scientist in the Department of Medical Microbiology at the University of the Free State (UFS) also looks at drug resistance in her research. This work informs decisions about how best to treat patients with multidrug-resistant TB (MDR-TB). 

She employs rapid molecular techniques to track one of Africa’s most serious diseases, tuberculosis (TB). 

Drug resistance
Scientists assist the National Health Laboratory Service and Department of Health in trying to refine the diagnostic tools to identify these cases earlier. Dr Van der Spoel van Dijk explains: “Until recently, it took up to two years to fine-tune treatment decisions for patients with MDR-TB. Patients get a cocktail of anti-TB drugs, but it takes time to find the right combination. Re-infection and relapse (patients stopping treatment for several reasons) add to the diagnostic and treatment management challenges.

Enormous impact
“Now doctors can reduce the time needed for diagnostic certainty to about seven days, while new drugs allow reduction of treatment from more than 18 to nine months. This can have an enormous impact on the life of many patients.”

Dr Van der Spoel van Dijk’s work forms part of research in the faculty looking at resistance development in TB strains. She is currently also doing her doctoral thesis on the differences and incidence of MDR-TB among adolescents versus adults. Dr Van der Spoel van Dijk says: “It is a complicated picture, but we hope to unravel it to support better diagnostic tools and patient care.”

As part of the National Health Laboratory Service, her department is playing an important role in TB diagnostics and the training of scientists and future pathologists. “Our work is contributing to the global vision to stop TB by 2035,” Dr Van der Spoel van Dijk says.

News Archive

Nothing beats hard work, says Kovsie
2011-10-13

 

Khethiwe Mtshali

Khethiwe Mtshali is a classic example of a go-getter. This hard-working 23-year-old student from Ladysmith, who is currently studying at our Qwaqwa Campus, strongly believes in her own abilities. She believes that hard work pays off and that a person will be richly rewarded if you give it your best. Khethiwe has recently returned from a month-long visit to China where she was stationed at the Fresh Water Fisheries Research Centre of the Chinese Academy of Fishery Sciences in Wuxi City.

“I was nominated to go to China to learn and conduct research, as South Africa lacks expertise in the field of food security and related fields of science,” says Khethiwe, a 2011 recipient of the Golden Key Award and an M.Sc.in Zoology student who specialises in Parasitology.
 
“The Chinese is a hard-working nation that I wish we could emulate as South Africans. Doing my research on parasitology of fish and other related agricultural diseases over there was a worthwhile experience that will not only benefit me as an individual, but the entire Parasitology Division of the Department of Zoology and Entomology at the Qwaqwa Campus. This research is surely going to put the university and the entire country in a better position to compete with the best in the field of parasitology,” Khethiwe said.
 
After completing her B.Sc. degree in 2008, Khethiwe worked as a teacher at Ezakheni High School for a year before she was summoned back to our university by her mentor and Head of the Department of Zoology and Entomology, Dr Oriel Thekisoe, where she studied towards an honours degree, which she passed with distinction last year.
 
“If it had not been for Dr Thekisoe, I think I would still be a teacher whose potential would not have been tapped to the maximum. I wish to thank him for pushing me to do my best at all times. He has taught me that where there’s a will, there’s a way,” Khethiwe said.
 
The best is yet to come for this proud Kovsie who can teach you a thing or two in Chinese!

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