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07 January 2018 Photo Charl Devenish
Researcher tackling drug-resistant TB through molecular methods
Dr Anneke van der Spoel van Dijk is invested in contributing to the global effort of stopping TB by 2035.

The work of Dr Anneke van der Spoel van Dijk investigates the spread of TB in the Free State population using techniques such as next generation sequencing, spoligotyping and MIRU-VNTR typing. Dr Van der Spoel van Dijk, a senior medical scientist in the Department of Medical Microbiology at the University of the Free State (UFS) also looks at drug resistance in her research. This work informs decisions about how best to treat patients with multidrug-resistant TB (MDR-TB). 

She employs rapid molecular techniques to track one of Africa’s most serious diseases, tuberculosis (TB). 

Drug resistance
Scientists assist the National Health Laboratory Service and Department of Health in trying to refine the diagnostic tools to identify these cases earlier. Dr Van der Spoel van Dijk explains: “Until recently, it took up to two years to fine-tune treatment decisions for patients with MDR-TB. Patients get a cocktail of anti-TB drugs, but it takes time to find the right combination. Re-infection and relapse (patients stopping treatment for several reasons) add to the diagnostic and treatment management challenges.

Enormous impact
“Now doctors can reduce the time needed for diagnostic certainty to about seven days, while new drugs allow reduction of treatment from more than 18 to nine months. This can have an enormous impact on the life of many patients.”

Dr Van der Spoel van Dijk’s work forms part of research in the faculty looking at resistance development in TB strains. She is currently also doing her doctoral thesis on the differences and incidence of MDR-TB among adolescents versus adults. Dr Van der Spoel van Dijk says: “It is a complicated picture, but we hope to unravel it to support better diagnostic tools and patient care.”

As part of the National Health Laboratory Service, her department is playing an important role in TB diagnostics and the training of scientists and future pathologists. “Our work is contributing to the global vision to stop TB by 2035,” Dr Van der Spoel van Dijk says.

News Archive

Rasool lauds our university
2011-10-24

 
At the dinner at the residence of the South African Ambassador to the USA, Mr Ebrahim Rasool, were, from the left: Prof. Debra Stewart, President of the Council of Graduate Schools in the USA; South African Ambassador, Mr Rasool; Prof. Jansen; and Prof. Molly Corbett Broad, President of the American Council on Education (ACE).

The Ambassador for South Africa to the United States of America (USA), Mr Ebrahim Rasool, recently hosted Prof. Jonathan Jansen, Vice-Chancellor and Rector of our university and a group of representatives from major science councils, foundations and universities at his home in Washington DC. Our university is the first South African university to be hosted at the official home of the Ambassador.

“The University of the Free State has shown South Africa and the world how to work with the past and how to make the past work for them. “You are a thought leader who had the privilege not to be comfortable with your own ideas of history; you understood the need to change and embraced it. You have moved the fastest towards racial and human togetherness of all the South African universities,” Mr Rasool said.
 
Prof. Jansen responded by saying that Africa needed strong academic universities and that had to be the focus of tertiary institutions across the continent. “We must create opportunities for people to be together and to learn from each other. The UFS is an experiment of human togetherness – and this experiment is taking off,” he said. 
 
During his visit to the USA, Prof. Jansen also discussed research partnerships and new placements for UFS staff and students through exchange visits.

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