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07 January 2018 Photo Charl Devenish
Researcher tackling drug-resistant TB through molecular methods
Dr Anneke van der Spoel van Dijk is invested in contributing to the global effort of stopping TB by 2035.

The work of Dr Anneke van der Spoel van Dijk investigates the spread of TB in the Free State population using techniques such as next generation sequencing, spoligotyping and MIRU-VNTR typing. Dr Van der Spoel van Dijk, a senior medical scientist in the Department of Medical Microbiology at the University of the Free State (UFS) also looks at drug resistance in her research. This work informs decisions about how best to treat patients with multidrug-resistant TB (MDR-TB). 

She employs rapid molecular techniques to track one of Africa’s most serious diseases, tuberculosis (TB). 

Drug resistance
Scientists assist the National Health Laboratory Service and Department of Health in trying to refine the diagnostic tools to identify these cases earlier. Dr Van der Spoel van Dijk explains: “Until recently, it took up to two years to fine-tune treatment decisions for patients with MDR-TB. Patients get a cocktail of anti-TB drugs, but it takes time to find the right combination. Re-infection and relapse (patients stopping treatment for several reasons) add to the diagnostic and treatment management challenges.

Enormous impact
“Now doctors can reduce the time needed for diagnostic certainty to about seven days, while new drugs allow reduction of treatment from more than 18 to nine months. This can have an enormous impact on the life of many patients.”

Dr Van der Spoel van Dijk’s work forms part of research in the faculty looking at resistance development in TB strains. She is currently also doing her doctoral thesis on the differences and incidence of MDR-TB among adolescents versus adults. Dr Van der Spoel van Dijk says: “It is a complicated picture, but we hope to unravel it to support better diagnostic tools and patient care.”

As part of the National Health Laboratory Service, her department is playing an important role in TB diagnostics and the training of scientists and future pathologists. “Our work is contributing to the global vision to stop TB by 2035,” Dr Van der Spoel van Dijk says.

News Archive

Global Leadership Summit takes a look at Higher Education in the South African context
2012-07-10

Since 1994 South Africa has achieved a lot in making higher education accessible to South Africans, but challenges still face us daily.

This was the message of a lecture by Dr Lis Lange, Senior Director at the Directorate for Institutional Research and Academic Planning (DIRAP) today at the Global Leadership Summit at the University of the Free State (UFS).

Dr Lange’s lecture focused on the Higher Education and Leadership for Change in South Africa.

In her lecture Dr Lange said in 1994 about 525 000 students, of which 47% were white students, enrolled in South African universities. White youth participation in South Africa was also far higher at 70% comparing to the 9% participation by African youth.

Dr Lange found that eighteen years into democracy, about 900 000 students enrol in South African universities of which the majority is African students. The number of female students also increased greatly.

“In general, youth participation in South Africa remains low. This is still more prevalent among African youth. We also experience a high drop-out rate in South African institutions of higher education.”

Dr Lange delivered this lecture on Monday as part of a series of conversations taking place at the UFS during the Global Leadership Summit. About 160 student and staff delegates are attending this summit and will take part in various critical dialogues. 

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