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07 January 2018 Photo Charl Devenish
Researcher tackling drug-resistant TB through molecular methods
Dr Anneke van der Spoel van Dijk is invested in contributing to the global effort of stopping TB by 2035.

The work of Dr Anneke van der Spoel van Dijk investigates the spread of TB in the Free State population using techniques such as next generation sequencing, spoligotyping and MIRU-VNTR typing. Dr Van der Spoel van Dijk, a senior medical scientist in the Department of Medical Microbiology at the University of the Free State (UFS) also looks at drug resistance in her research. This work informs decisions about how best to treat patients with multidrug-resistant TB (MDR-TB). 

She employs rapid molecular techniques to track one of Africa’s most serious diseases, tuberculosis (TB). 

Drug resistance
Scientists assist the National Health Laboratory Service and Department of Health in trying to refine the diagnostic tools to identify these cases earlier. Dr Van der Spoel van Dijk explains: “Until recently, it took up to two years to fine-tune treatment decisions for patients with MDR-TB. Patients get a cocktail of anti-TB drugs, but it takes time to find the right combination. Re-infection and relapse (patients stopping treatment for several reasons) add to the diagnostic and treatment management challenges.

Enormous impact
“Now doctors can reduce the time needed for diagnostic certainty to about seven days, while new drugs allow reduction of treatment from more than 18 to nine months. This can have an enormous impact on the life of many patients.”

Dr Van der Spoel van Dijk’s work forms part of research in the faculty looking at resistance development in TB strains. She is currently also doing her doctoral thesis on the differences and incidence of MDR-TB among adolescents versus adults. Dr Van der Spoel van Dijk says: “It is a complicated picture, but we hope to unravel it to support better diagnostic tools and patient care.”

As part of the National Health Laboratory Service, her department is playing an important role in TB diagnostics and the training of scientists and future pathologists. “Our work is contributing to the global vision to stop TB by 2035,” Dr Van der Spoel van Dijk says.

News Archive

‘Global financial crisis is far from over’
2012-09-09

At the lecture were, from the left: Dr Arno van Niekerk (Department of Economy), Dr Francois Strydom (Centre for Teaching and Learning), Dr Mallory du Plooy (UFS101), Ms Gill Marcus, Governor of the Reserve Bank, and Lauren Hing and Louise Strydom of the UFS101 office.
Photo: Leatitia Pienaar.
6 September 2012

The global financial crisis the world has been experiencing since 2008 is far from over. In fact, Gill Marcus, Governor of the South African Reserve Bank, expects it to last for the next five years. “It is the longest financial crisis in history,” she said.

Ms Marcus lectured in the new UFS101 course of the university. The course was implemented at the beginning of the year and is aimed at broadening the world for new first-year students. About 2 000 students are taking the course.

Ms Marcus brought globalisation home and explained how activities in the international area impact on the lives of South Africans. She said South Africa was not excluded from the effect of global crises. Ms Marcus also said that South Africa was one of only a few countries in the world not experiencing a banking crisis due to strict controls in place, but more could be done.

“The big question is how to make sure that the South African banking system stays sound,” she said.

On a question about the debt of South Africans, she said it was important for South Africans to live within their means. “If we want to afford our new development, we need a savings percentage of 25 percent.” South Africa needs foreign capital investment to supplement the low local savings.

“It is difficult to resist all aspects of globalisation. Some can be to our advantage, but the others pose tremendous challenges.”

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