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07 January 2018 Photo Charl Devenish
Researcher tackling drug-resistant TB through molecular methods
Dr Anneke van der Spoel van Dijk is invested in contributing to the global effort of stopping TB by 2035.

The work of Dr Anneke van der Spoel van Dijk investigates the spread of TB in the Free State population using techniques such as next generation sequencing, spoligotyping and MIRU-VNTR typing. Dr Van der Spoel van Dijk, a senior medical scientist in the Department of Medical Microbiology at the University of the Free State (UFS) also looks at drug resistance in her research. This work informs decisions about how best to treat patients with multidrug-resistant TB (MDR-TB). 

She employs rapid molecular techniques to track one of Africa’s most serious diseases, tuberculosis (TB). 

Drug resistance
Scientists assist the National Health Laboratory Service and Department of Health in trying to refine the diagnostic tools to identify these cases earlier. Dr Van der Spoel van Dijk explains: “Until recently, it took up to two years to fine-tune treatment decisions for patients with MDR-TB. Patients get a cocktail of anti-TB drugs, but it takes time to find the right combination. Re-infection and relapse (patients stopping treatment for several reasons) add to the diagnostic and treatment management challenges.

Enormous impact
“Now doctors can reduce the time needed for diagnostic certainty to about seven days, while new drugs allow reduction of treatment from more than 18 to nine months. This can have an enormous impact on the life of many patients.”

Dr Van der Spoel van Dijk’s work forms part of research in the faculty looking at resistance development in TB strains. She is currently also doing her doctoral thesis on the differences and incidence of MDR-TB among adolescents versus adults. Dr Van der Spoel van Dijk says: “It is a complicated picture, but we hope to unravel it to support better diagnostic tools and patient care.”

As part of the National Health Laboratory Service, her department is playing an important role in TB diagnostics and the training of scientists and future pathologists. “Our work is contributing to the global vision to stop TB by 2035,” Dr Van der Spoel van Dijk says.

News Archive

Postgraduate School and Faculty of Law receive Rector during discussion with emerging researchers
2012-09-11

A session of the special programme for upcoming researchers was attended by, from the left: Denine Smit, Prof. Jonathan Jansen, Prof. Voet du Plessis of the Department of Mercantile Law and Marda Horn; back: Glancina Mokone, Albert Nell, Pieter Brits, Prof. Neil Roos, Director of the UFS’s Postgraduate School and Jamie Faber.
Photo: Leonie Bolleurs
11 September 2012

 Prof. Jonathan Jansen, Vice-Chancellor and Rector of the university, recently addressed six Ph.D. students and their supervisors in the Faculty of Law as part of a special programme of the Postgraduate School for emerging researchers. Prof. Jansen contextualised his lecture on the impact and significance of research, “How do you determine that the important and bigger questions in your research are addressed to ensure the impact thereof?” in his discussion with the researchers. Based on the model of international postgraduate seminars, the researchers set out their field of study to Prof. Jansen and the audience. Suggestions were then made on how to increase the intellectual impact and theoretical depth of academic argumentation.

According to Prof. Neil Roos, Director of the Postgraduate School, together with Prof. Jackie du Toit and Prof. Corli Witthuhn, Academic Coordinators for the Vice Chancellor’s Prestige Scholar Programme, the aim of the programme is to provide support to emerging researchers on postgraduate level similar to the Prestige Scholar Programme.

“The initiative is being rolled out in a faculty-specific way. In consultation with the deans, the specific needs in the faculty are determined, which in turn determines the approach,” says Prof. Roos.

The six students are all involved at the university in various capacities, and are studying towards a Ph.D. in Law. They are outstanding candidates who are being funded by the Postgraduate School in order to empower postgraduate students to greater reach, internationalisation and the establishment of long-term academic networks. The programme is coordinated in the Faculty of Law by Prof. Loot Pretorius.

Two upcoming researchers in the Faculty of Theology and one in Nursing joined the group for Prof. Jansen’s lecture on significant research.

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