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07 January 2018 Photo Charl Devenish
Researcher tackling drug-resistant TB through molecular methods
Dr Anneke van der Spoel van Dijk is invested in contributing to the global effort of stopping TB by 2035.

The work of Dr Anneke van der Spoel van Dijk investigates the spread of TB in the Free State population using techniques such as next generation sequencing, spoligotyping and MIRU-VNTR typing. Dr Van der Spoel van Dijk, a senior medical scientist in the Department of Medical Microbiology at the University of the Free State (UFS) also looks at drug resistance in her research. This work informs decisions about how best to treat patients with multidrug-resistant TB (MDR-TB). 

She employs rapid molecular techniques to track one of Africa’s most serious diseases, tuberculosis (TB). 

Drug resistance
Scientists assist the National Health Laboratory Service and Department of Health in trying to refine the diagnostic tools to identify these cases earlier. Dr Van der Spoel van Dijk explains: “Until recently, it took up to two years to fine-tune treatment decisions for patients with MDR-TB. Patients get a cocktail of anti-TB drugs, but it takes time to find the right combination. Re-infection and relapse (patients stopping treatment for several reasons) add to the diagnostic and treatment management challenges.

Enormous impact
“Now doctors can reduce the time needed for diagnostic certainty to about seven days, while new drugs allow reduction of treatment from more than 18 to nine months. This can have an enormous impact on the life of many patients.”

Dr Van der Spoel van Dijk’s work forms part of research in the faculty looking at resistance development in TB strains. She is currently also doing her doctoral thesis on the differences and incidence of MDR-TB among adolescents versus adults. Dr Van der Spoel van Dijk says: “It is a complicated picture, but we hope to unravel it to support better diagnostic tools and patient care.”

As part of the National Health Laboratory Service, her department is playing an important role in TB diagnostics and the training of scientists and future pathologists. “Our work is contributing to the global vision to stop TB by 2035,” Dr Van der Spoel van Dijk says.

News Archive

Afrikaans place names were not only given by Afrikaner people, says professor.
2012-09-25

Prof. Peter Raper delivering his lecture on South African place names.
25 September 2012

 Prof. Peter Raper, honorary professor at the Department of Linguistics and Language Practice, delivered a public lecture in Clarens earlier this month. The theme of the lecture was “From Stone Age to GPS: The fourth edition of the South African Place Names Dictionary”.

Prof. Raper shared the historical development of the project as well as the challenges and other interesting observations associated with the topic. He elaborated on the dramatic change in the focus of his research on place names in South Africa.

It was previously assumed that all of the Afrikaans place names were given by the Afrikaner people and that changing these place names was consistent with the mandate of the South African Geographical Names Council (SAGNC) to transform place names. Prof. Raper said more in-depth research revealed that a significant number of place names are actually translations of original San names – into Afrikaans, Khoi and the Bantu languages. He told the audience that given the constitutional stipulation that no cultural group’s heritage may be removed, this discovery calls into the question the modus operandi of the SAGNC.

Prof. Raper’s lecture was part of the conference programme of the Third International MIDP IV Symposium that took place on the Qwaqwa campus. The MIDP (Multilingual Information Development Programme) is a project sponsored by the Province of Antwerp. The theme for this year’s symposium was “Multilingualism for Empowerment” and was presented in collaboration with the University of Antwerp.

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