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07 January 2018 Photo Charl Devenish
Researcher tackling drug-resistant TB through molecular methods
Dr Anneke van der Spoel van Dijk is invested in contributing to the global effort of stopping TB by 2035.

The work of Dr Anneke van der Spoel van Dijk investigates the spread of TB in the Free State population using techniques such as next generation sequencing, spoligotyping and MIRU-VNTR typing. Dr Van der Spoel van Dijk, a senior medical scientist in the Department of Medical Microbiology at the University of the Free State (UFS) also looks at drug resistance in her research. This work informs decisions about how best to treat patients with multidrug-resistant TB (MDR-TB). 

She employs rapid molecular techniques to track one of Africa’s most serious diseases, tuberculosis (TB). 

Drug resistance
Scientists assist the National Health Laboratory Service and Department of Health in trying to refine the diagnostic tools to identify these cases earlier. Dr Van der Spoel van Dijk explains: “Until recently, it took up to two years to fine-tune treatment decisions for patients with MDR-TB. Patients get a cocktail of anti-TB drugs, but it takes time to find the right combination. Re-infection and relapse (patients stopping treatment for several reasons) add to the diagnostic and treatment management challenges.

Enormous impact
“Now doctors can reduce the time needed for diagnostic certainty to about seven days, while new drugs allow reduction of treatment from more than 18 to nine months. This can have an enormous impact on the life of many patients.”

Dr Van der Spoel van Dijk’s work forms part of research in the faculty looking at resistance development in TB strains. She is currently also doing her doctoral thesis on the differences and incidence of MDR-TB among adolescents versus adults. Dr Van der Spoel van Dijk says: “It is a complicated picture, but we hope to unravel it to support better diagnostic tools and patient care.”

As part of the National Health Laboratory Service, her department is playing an important role in TB diagnostics and the training of scientists and future pathologists. “Our work is contributing to the global vision to stop TB by 2035,” Dr Van der Spoel van Dijk says.

News Archive

Student organisation tackles difficult questions in debate
2012-05-12

 

At the debate were, from the left: Danie Jacobs, Head of the Centre for Business Dynamics, Mhlanganisi Madlongolwana, Nombuso Ndlovu and Prof. JP Landman.
Photo: Leatitia Pienaar

 

“South Africa is consumed by a monster, namely the lack of critical thinking and dialogue with regard to our problems. Now is the time to make radical changes.” This is according to Nombuso Ndlovu, who spoke at the first debate in a series of Commercio and the UFS Business School.

“Young people are more interested in social gatherings than applying their minds to the problems of South Africa,” she said. Nombuso is the CEO of Commercio.

Commercio is the student organisation in the Faculty of Economic and Management Sciences. Two teams, one positive and one negative, debated the topic: Is South Africa’s current economic direction viable?

What emerged from the debate was that our students are well-aware of what is going on in our economy and that people cannot just sit back and expect government to deliver. Every individual has a responsibility. South Africa has a “democratic deficit” society, a “corruption-stricken economy” and “economic activism” is necessary to get the economy on the right path.

Prof. JP Landman, Visiting Professor at the Business School, economic advisor, analyst, columnist and also managing director of the Aardklop Arts Festival, was the expert panel member. He said the critical issue in South Africa is “how do you distribute wealth while keeping things going?”

“It is fantastic that South Africans have developed a collective repulsiveness for corruption.” People must know what underpins society and where aggression comes from.
– Leatitia Pienaar.

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