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07 January 2018 Photo Charl Devenish
Researcher tackling drug-resistant TB through molecular methods
Dr Anneke van der Spoel van Dijk is invested in contributing to the global effort of stopping TB by 2035.

The work of Dr Anneke van der Spoel van Dijk investigates the spread of TB in the Free State population using techniques such as next generation sequencing, spoligotyping and MIRU-VNTR typing. Dr Van der Spoel van Dijk, a senior medical scientist in the Department of Medical Microbiology at the University of the Free State (UFS) also looks at drug resistance in her research. This work informs decisions about how best to treat patients with multidrug-resistant TB (MDR-TB). 

She employs rapid molecular techniques to track one of Africa’s most serious diseases, tuberculosis (TB). 

Drug resistance
Scientists assist the National Health Laboratory Service and Department of Health in trying to refine the diagnostic tools to identify these cases earlier. Dr Van der Spoel van Dijk explains: “Until recently, it took up to two years to fine-tune treatment decisions for patients with MDR-TB. Patients get a cocktail of anti-TB drugs, but it takes time to find the right combination. Re-infection and relapse (patients stopping treatment for several reasons) add to the diagnostic and treatment management challenges.

Enormous impact
“Now doctors can reduce the time needed for diagnostic certainty to about seven days, while new drugs allow reduction of treatment from more than 18 to nine months. This can have an enormous impact on the life of many patients.”

Dr Van der Spoel van Dijk’s work forms part of research in the faculty looking at resistance development in TB strains. She is currently also doing her doctoral thesis on the differences and incidence of MDR-TB among adolescents versus adults. Dr Van der Spoel van Dijk says: “It is a complicated picture, but we hope to unravel it to support better diagnostic tools and patient care.”

As part of the National Health Laboratory Service, her department is playing an important role in TB diagnostics and the training of scientists and future pathologists. “Our work is contributing to the global vision to stop TB by 2035,” Dr Van der Spoel van Dijk says.

News Archive

Australian academics present research seminar on education
2012-11-14

At the research seminar were, from the left Prof. Marie Brennan, Prof. Melanie Walker and Dr Lew Zipin.
Photo: Amanda Tongha
14 November 2012

The Research Centre on Higher Education, Development and Capabilities recently hosted two international visitors, Prof. Marie Brennan and Dr Lew Zipin from Victoria University in Australia. They discussed future visits and research collaboration with Prof. Melanie Walker, Professor of Higher Education and Human Development. They presented a well-attended research seminar on ‘Educating for futures in marginalized regions: a sociological framework for rethinking and researching aspirations’.

Prof. Brennan and Dr Zipin have been involved in researching education for social justice in teacher education and higher education in Australia for many years. Most recently, they have been researchers on prestigious Australian Research Council projects. These include: (i) Capacitating Student Aspirations in Classrooms and Communities in a High Poverty Region, 2012-2014; and (ii) Pursuing equity in high poverty rural schools: improving learning through rich accountabilities, 2010-2012. They recently co-edited Re-positioning University Governance and Academic Work that was published by Sense Publications in 2010.

 

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