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07 January 2018 Photo Charl Devenish
Researcher tackling drug-resistant TB through molecular methods
Dr Anneke van der Spoel van Dijk is invested in contributing to the global effort of stopping TB by 2035.

The work of Dr Anneke van der Spoel van Dijk investigates the spread of TB in the Free State population using techniques such as next generation sequencing, spoligotyping and MIRU-VNTR typing. Dr Van der Spoel van Dijk, a senior medical scientist in the Department of Medical Microbiology at the University of the Free State (UFS) also looks at drug resistance in her research. This work informs decisions about how best to treat patients with multidrug-resistant TB (MDR-TB). 

She employs rapid molecular techniques to track one of Africa’s most serious diseases, tuberculosis (TB). 

Drug resistance
Scientists assist the National Health Laboratory Service and Department of Health in trying to refine the diagnostic tools to identify these cases earlier. Dr Van der Spoel van Dijk explains: “Until recently, it took up to two years to fine-tune treatment decisions for patients with MDR-TB. Patients get a cocktail of anti-TB drugs, but it takes time to find the right combination. Re-infection and relapse (patients stopping treatment for several reasons) add to the diagnostic and treatment management challenges.

Enormous impact
“Now doctors can reduce the time needed for diagnostic certainty to about seven days, while new drugs allow reduction of treatment from more than 18 to nine months. This can have an enormous impact on the life of many patients.”

Dr Van der Spoel van Dijk’s work forms part of research in the faculty looking at resistance development in TB strains. She is currently also doing her doctoral thesis on the differences and incidence of MDR-TB among adolescents versus adults. Dr Van der Spoel van Dijk says: “It is a complicated picture, but we hope to unravel it to support better diagnostic tools and patient care.”

As part of the National Health Laboratory Service, her department is playing an important role in TB diagnostics and the training of scientists and future pathologists. “Our work is contributing to the global vision to stop TB by 2035,” Dr Van der Spoel van Dijk says.

News Archive

New Head for the School of Mathematics, Natural Sciences and Technology Education
2013-02-27

27 February 2013

Prof Sechaba Mahlomoholo from the Faculty of Education at the University of the Free State was recently appointed as Head of the School of Mathematics, Natural Sciences and Technology Education (SMNSTE).

As head of the school, his duties will include improving the learning, teaching and curricula of maths, natural sciences and technology at school and at post-school levels.

“The solution seems to be to move the SMNSTE into a very intensive praxis mode where, through our high-level research-based classroom practices, we can formulate strategies together with teachers, parents, learners and the Department of Education, to enhance learner performance in the abovementioned subjects. Our plan, therefore, is to facilitate the establishment of closely knit learning communities of practice around these three subjects, with the SMNSTE being the epicentre of thought and action, while schools, mainly in the Free State, will serve as other nodal points for this intensive praxis. We believe that the SMNSTE will come to its fullness once student and learner performance is respectable, and as such positions our country favourably among the community of nations. SMNSTE is a national facility which has to respond to national challenges effectively.”

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