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07 January 2018 Photo Charl Devenish
Researcher tackling drug-resistant TB through molecular methods
Dr Anneke van der Spoel van Dijk is invested in contributing to the global effort of stopping TB by 2035.

The work of Dr Anneke van der Spoel van Dijk investigates the spread of TB in the Free State population using techniques such as next generation sequencing, spoligotyping and MIRU-VNTR typing. Dr Van der Spoel van Dijk, a senior medical scientist in the Department of Medical Microbiology at the University of the Free State (UFS) also looks at drug resistance in her research. This work informs decisions about how best to treat patients with multidrug-resistant TB (MDR-TB). 

She employs rapid molecular techniques to track one of Africa’s most serious diseases, tuberculosis (TB). 

Drug resistance
Scientists assist the National Health Laboratory Service and Department of Health in trying to refine the diagnostic tools to identify these cases earlier. Dr Van der Spoel van Dijk explains: “Until recently, it took up to two years to fine-tune treatment decisions for patients with MDR-TB. Patients get a cocktail of anti-TB drugs, but it takes time to find the right combination. Re-infection and relapse (patients stopping treatment for several reasons) add to the diagnostic and treatment management challenges.

Enormous impact
“Now doctors can reduce the time needed for diagnostic certainty to about seven days, while new drugs allow reduction of treatment from more than 18 to nine months. This can have an enormous impact on the life of many patients.”

Dr Van der Spoel van Dijk’s work forms part of research in the faculty looking at resistance development in TB strains. She is currently also doing her doctoral thesis on the differences and incidence of MDR-TB among adolescents versus adults. Dr Van der Spoel van Dijk says: “It is a complicated picture, but we hope to unravel it to support better diagnostic tools and patient care.”

As part of the National Health Laboratory Service, her department is playing an important role in TB diagnostics and the training of scientists and future pathologists. “Our work is contributing to the global vision to stop TB by 2035,” Dr Van der Spoel van Dijk says.

News Archive

University grooms future leaders
2013-02-28

Nangamso Koza, volunteers and learners who participated in the RCL training programme.
Photo: Linda Fekisi
28 February 2013

The UFS recently hosted a group of Representative Council of Learners (RCL) from 24 high schools in the Free State. The learners participated in a RCL training programme, the first of its kind, which will take place on a quarterly basis.

The learners were welcomed by Prof Jonathan Jansen, Vice-Chancellor and Rector of the university. Prof Jansen emphasised the need for academic excellence in his welcoming speech, telling learners not to settle for a pass rate of 30%. He motivated them to study hard in order to reap rewards, regardless of their disadvantaged backgrounds. He told them about first-year student, Zandile Kwela and others, who excelled in the 2012 matric exams despite disadvantaged backgrounds.

Nangamso Koza, Research Assistant in the office of the Vice-Rector: External Relations, who helped to coordinate the programme, said leadership development is vital, as early as the basic education phase. “The objective was to offer the RCL some of the skills and knowledge we have, to enable them to dream out of the box."

Mr Pura Mgolombane, Assistant-Dean of Student Affairs, shared what student leadership is all about, the values that a leader needs to have and the relevant constitutional documentation and acts they need to know.

Madineo Mofokeng, an RCL member from Excelsior Combined School, describes her experience as a great one. “I learnt many things that will help me improve my school. I also learnt that by believing in yourself, you can do anything you put your mind to,” she added.


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