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07 January 2018 Photo Charl Devenish
Researcher tackling drug-resistant TB through molecular methods
Dr Anneke van der Spoel van Dijk is invested in contributing to the global effort of stopping TB by 2035.

The work of Dr Anneke van der Spoel van Dijk investigates the spread of TB in the Free State population using techniques such as next generation sequencing, spoligotyping and MIRU-VNTR typing. Dr Van der Spoel van Dijk, a senior medical scientist in the Department of Medical Microbiology at the University of the Free State (UFS) also looks at drug resistance in her research. This work informs decisions about how best to treat patients with multidrug-resistant TB (MDR-TB). 

She employs rapid molecular techniques to track one of Africa’s most serious diseases, tuberculosis (TB). 

Drug resistance
Scientists assist the National Health Laboratory Service and Department of Health in trying to refine the diagnostic tools to identify these cases earlier. Dr Van der Spoel van Dijk explains: “Until recently, it took up to two years to fine-tune treatment decisions for patients with MDR-TB. Patients get a cocktail of anti-TB drugs, but it takes time to find the right combination. Re-infection and relapse (patients stopping treatment for several reasons) add to the diagnostic and treatment management challenges.

Enormous impact
“Now doctors can reduce the time needed for diagnostic certainty to about seven days, while new drugs allow reduction of treatment from more than 18 to nine months. This can have an enormous impact on the life of many patients.”

Dr Van der Spoel van Dijk’s work forms part of research in the faculty looking at resistance development in TB strains. She is currently also doing her doctoral thesis on the differences and incidence of MDR-TB among adolescents versus adults. Dr Van der Spoel van Dijk says: “It is a complicated picture, but we hope to unravel it to support better diagnostic tools and patient care.”

As part of the National Health Laboratory Service, her department is playing an important role in TB diagnostics and the training of scientists and future pathologists. “Our work is contributing to the global vision to stop TB by 2035,” Dr Van der Spoel van Dijk says.

News Archive

Two academics will be sorely missed
2013-04-02

  

Prof Andrew Marston and Prof Bannie Britz
Photo: Supplied
02 April 2013

The staff and students of the University of the Free State (UFS) are deeply saddened by the recent passing in Bloemfontein of two of the university’s most esteemed and renowned academics, Prof Bannie Britz and Prof Andrew Marston.

Prof Britz was the Head of the Department of Architecture from 1992 to 2000. He was renowned in his field, winning numerous prizes for Architecture, including the Gold Medal for Architecture from the South African Academy of Arts and Sciences.

“As professional architect and urban designer, Prof Britz was a much awarded architect who received numerous award of merit from the South African Institute of Architects for buildings erected in South Africa over the years,” said Martie Bitzer, Head of the Department of Architecture.

Apart from his acclaim elsewhere, Prof Britz also played a major role in the day-to-day activities of university’s staff and students. He was responsible for the design of the many walkways on campus and the refurbishment of the Main Building on the Bloemfontein Campus. For the many contributions in his field, Prof Britz was awarded an Honorary Doctorate by the UFS in 2007.

Prof Andrew Marston, a specialist in natural product chemistry and methods associated with the isolation and analysis of medically important chemicals from plants, was appointed from Geneva, Switzerland in 2009 under the UFS Strategic Cluster for Advanced Biomolecular Research.

He obtained a B-rating from the National Research Foundation (NRF) in 2011, and was consequently appointed as a senior professor in die UFS Senior Professor Programme. “He has made valuable contributions to the UFS in terms of teaching and postgraduate supervision, as well as research. In his short stay at the UFS, he already co-authored more than ten papers in international chemistry literature,” said Prof André Roodt, Head of the Department of Chemistry.

His research group was part of a multilateral agreement in the European Union (EU) with a number of African and three European universities. He obtained new research funding from the Seventh Framework Programme of the EU for the Building Sustainable Research Capacity on Plants for Better Public Health in Africa project, from the Norwegian Research Council for bioprospecting and the isolation and structure determination of compounds from plants and algae, and from the South African Rooibos Tea Council.

The memorial service for Prof Britz took place on Friday 5 April 2013 in the Berg-en-Dal Dutch Reformed Church in Bloemfontein. The service for Prof Marston took place in the Trinity Church, Charles Street, Bloemfontein.

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