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07 January 2018 Photo Charl Devenish
Researcher tackling drug-resistant TB through molecular methods
Dr Anneke van der Spoel van Dijk is invested in contributing to the global effort of stopping TB by 2035.

The work of Dr Anneke van der Spoel van Dijk investigates the spread of TB in the Free State population using techniques such as next generation sequencing, spoligotyping and MIRU-VNTR typing. Dr Van der Spoel van Dijk, a senior medical scientist in the Department of Medical Microbiology at the University of the Free State (UFS) also looks at drug resistance in her research. This work informs decisions about how best to treat patients with multidrug-resistant TB (MDR-TB). 

She employs rapid molecular techniques to track one of Africa’s most serious diseases, tuberculosis (TB). 

Drug resistance
Scientists assist the National Health Laboratory Service and Department of Health in trying to refine the diagnostic tools to identify these cases earlier. Dr Van der Spoel van Dijk explains: “Until recently, it took up to two years to fine-tune treatment decisions for patients with MDR-TB. Patients get a cocktail of anti-TB drugs, but it takes time to find the right combination. Re-infection and relapse (patients stopping treatment for several reasons) add to the diagnostic and treatment management challenges.

Enormous impact
“Now doctors can reduce the time needed for diagnostic certainty to about seven days, while new drugs allow reduction of treatment from more than 18 to nine months. This can have an enormous impact on the life of many patients.”

Dr Van der Spoel van Dijk’s work forms part of research in the faculty looking at resistance development in TB strains. She is currently also doing her doctoral thesis on the differences and incidence of MDR-TB among adolescents versus adults. Dr Van der Spoel van Dijk says: “It is a complicated picture, but we hope to unravel it to support better diagnostic tools and patient care.”

As part of the National Health Laboratory Service, her department is playing an important role in TB diagnostics and the training of scientists and future pathologists. “Our work is contributing to the global vision to stop TB by 2035,” Dr Van der Spoel van Dijk says.

News Archive

University is proud of its women in science
2013-08-17

 

Dr Marieka Gryzenhout
Photo: Sonia Small
19 August 2013

Two lecturers in the Department of Plant Sciences received national recognition for their research at the Women in Science Award 2013 function of the Department of Science and Technology (DST) on Friday 16 August 2013. Dr Marieka Gryzenhout received the award as Young Women Scientist and Prof Maryke Labuschagne was first runner-up in the category Distinguished Women Researcher, both in Life Sciences.

The third award-winner was Rose Lekhooa in the Doctoral Fellowship category. She is studying toward a PhD in Pharmacology and said the fellowship will enable her to attend seminars and workshops internationally.

Friday’s award was the second, in as many months, for Dr Gryzenhout. She received the TW Kambule NRF-NSTF Award as emerging researcher in June 2013. She was the recipient of the International Union of Forestry Research Organizations’ Outstanding Doctoral Research award in 2010.

Prof Jonathan Jansen, Vice-Chancellor and Rector of the UFS, said, “Dr Gryzenhout represents one of a growing group of very impressive young scientists at the university who are emerging as leading international scholars in their fields.

“Her international leadership in mycology research has already made significant impacts on the African continent and beyond. The university will continue to invest in these young academic stars through its Prestige Scholars Programme where scholars like Dr Gryzenhout are increasingly well-placed to be the next generation of scientific leaders in the world.”

“It as a great privilege to receive the award, especially as second one in this year,” Dr Gryzenhout said. She established a research programme, Mycotoxigenic and Phytopathogenic Fungi, at the UFS. She is president of the African Mycological Association and general secretary of the International Society for Fungal Conservation. She is also a member of the Nomenclature Committee for Fungi – a permanent committee of the International Botanical Congress.

Prof Labuschagne received the African Union Kwame Nkrumah award for life and earth sciences in 2011, and the National Agriculturalist of the Year Award and the National Science and Technology Forum (NSTF) Award for research-capacity development over the last five to ten years, both in 2008.

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