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07 January 2018 Photo Charl Devenish
Researcher tackling drug-resistant TB through molecular methods
Dr Anneke van der Spoel van Dijk is invested in contributing to the global effort of stopping TB by 2035.

The work of Dr Anneke van der Spoel van Dijk investigates the spread of TB in the Free State population using techniques such as next generation sequencing, spoligotyping and MIRU-VNTR typing. Dr Van der Spoel van Dijk, a senior medical scientist in the Department of Medical Microbiology at the University of the Free State (UFS) also looks at drug resistance in her research. This work informs decisions about how best to treat patients with multidrug-resistant TB (MDR-TB). 

She employs rapid molecular techniques to track one of Africa’s most serious diseases, tuberculosis (TB). 

Drug resistance
Scientists assist the National Health Laboratory Service and Department of Health in trying to refine the diagnostic tools to identify these cases earlier. Dr Van der Spoel van Dijk explains: “Until recently, it took up to two years to fine-tune treatment decisions for patients with MDR-TB. Patients get a cocktail of anti-TB drugs, but it takes time to find the right combination. Re-infection and relapse (patients stopping treatment for several reasons) add to the diagnostic and treatment management challenges.

Enormous impact
“Now doctors can reduce the time needed for diagnostic certainty to about seven days, while new drugs allow reduction of treatment from more than 18 to nine months. This can have an enormous impact on the life of many patients.”

Dr Van der Spoel van Dijk’s work forms part of research in the faculty looking at resistance development in TB strains. She is currently also doing her doctoral thesis on the differences and incidence of MDR-TB among adolescents versus adults. Dr Van der Spoel van Dijk says: “It is a complicated picture, but we hope to unravel it to support better diagnostic tools and patient care.”

As part of the National Health Laboratory Service, her department is playing an important role in TB diagnostics and the training of scientists and future pathologists. “Our work is contributing to the global vision to stop TB by 2035,” Dr Van der Spoel van Dijk says.

News Archive

‘Your capacity for change is limitless’
2013-09-13

 

Ready for the world - students taking part in the 2013 Leadership for Change programme getting ready to travel to universities in the USA, Europe and Asia.
Photo: Johan Roux
12 September 2013

 “You will change this campus, city, country, continent and the world, because you have the capacity for greatness,” Prof Jonathan Jansen, Vice-Chancellor and Rector of the University of the Free State (UFS), said.

He addressed the 2013 group of first-year students in the Leadership for Change programme at a farewell function before they will leave for universities abroad. The first 104 students from the 2013 total of 144 will depart on 18 September and return on 3 October 2013. The second group of 40 students will be abroad from 11 to 25 January 2014. The students are from the Bloemfontein and Qwaqwa Campuses. They will be accompanied by mentors from the UFS.

The students will visit 17 universities in the USA, Europe and Asia.

The first 71 first-year students in the Leadership for Change programme were sent abroad for two weeks in September 2010 to get intense exposure to the academic, social, cultural and residential lives of students in the USA. In 2011 the student number more than doubled and universities in Europe were included. In July 2012 the programme brought students from around the globe to the UFS for the Global Leadership Summit.

Prof Jansen inspired the young leaders, saying, “If you learn leadership values in your four years of study, a change will come. Build the new value system and take it into the country. Your capacity for change is limitless.”

He encouraged them to learn to know the stranger, not only abroad, but also the beggar at the street corner. “Learn to be comfortable with the beggar, as well as with the professor in the classroom.”

A stringent evaluation and training programme preceded the group’s visit abroad, and Prof Jansen could not formulate their achievement better: “I cannot tell you how proud I am of you.”

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