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07 January 2018 Photo Charl Devenish
Researcher tackling drug-resistant TB through molecular methods
Dr Anneke van der Spoel van Dijk is invested in contributing to the global effort of stopping TB by 2035.

The work of Dr Anneke van der Spoel van Dijk investigates the spread of TB in the Free State population using techniques such as next generation sequencing, spoligotyping and MIRU-VNTR typing. Dr Van der Spoel van Dijk, a senior medical scientist in the Department of Medical Microbiology at the University of the Free State (UFS) also looks at drug resistance in her research. This work informs decisions about how best to treat patients with multidrug-resistant TB (MDR-TB). 

She employs rapid molecular techniques to track one of Africa’s most serious diseases, tuberculosis (TB). 

Drug resistance
Scientists assist the National Health Laboratory Service and Department of Health in trying to refine the diagnostic tools to identify these cases earlier. Dr Van der Spoel van Dijk explains: “Until recently, it took up to two years to fine-tune treatment decisions for patients with MDR-TB. Patients get a cocktail of anti-TB drugs, but it takes time to find the right combination. Re-infection and relapse (patients stopping treatment for several reasons) add to the diagnostic and treatment management challenges.

Enormous impact
“Now doctors can reduce the time needed for diagnostic certainty to about seven days, while new drugs allow reduction of treatment from more than 18 to nine months. This can have an enormous impact on the life of many patients.”

Dr Van der Spoel van Dijk’s work forms part of research in the faculty looking at resistance development in TB strains. She is currently also doing her doctoral thesis on the differences and incidence of MDR-TB among adolescents versus adults. Dr Van der Spoel van Dijk says: “It is a complicated picture, but we hope to unravel it to support better diagnostic tools and patient care.”

As part of the National Health Laboratory Service, her department is playing an important role in TB diagnostics and the training of scientists and future pathologists. “Our work is contributing to the global vision to stop TB by 2035,” Dr Van der Spoel van Dijk says.

News Archive

Discussion on mass violence and genocide in Africa
2013-09-25

25 September 2013

Africa’s contested pasts have frequently been characterised by violence. The manner of the continent’s subjugation to colonial rule; processes of indigenous resistance and accommodation; patterns of dispossession and accumulation; the construction and reconstruction of gendered identities; liberation movement dynamics; and the postcolonial politics of patronage have all shaped African experiences of violence and antagonisms.

To this list could be added past and present manifestations of xenophobia; the struggle for scarce resources in conditions of extreme inequality and climate change; and many more.

Looking at the above, the Institute for Reconciliation and Social Justice will host a colloquium on Mass Violence and genocide in Africa: Colonial and postcolonial perspectives on 26 September 2013.

The aim of the colloquium is to account, through a mixture of historical case studies and over-arching contemporary thematic and conceptual analyses, for a spectrum encompassing individual trauma, mass violence and genocide.

Time: 08:00-16:45
Place: Institute for Reconciliation and Social Justice (DF Malherbe House and the Centenary Complex)
RSVP: DemanA@ufs.ac.za

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