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07 January 2018 Photo Charl Devenish
Researcher tackling drug-resistant TB through molecular methods
Dr Anneke van der Spoel van Dijk is invested in contributing to the global effort of stopping TB by 2035.

The work of Dr Anneke van der Spoel van Dijk investigates the spread of TB in the Free State population using techniques such as next generation sequencing, spoligotyping and MIRU-VNTR typing. Dr Van der Spoel van Dijk, a senior medical scientist in the Department of Medical Microbiology at the University of the Free State (UFS) also looks at drug resistance in her research. This work informs decisions about how best to treat patients with multidrug-resistant TB (MDR-TB). 

She employs rapid molecular techniques to track one of Africa’s most serious diseases, tuberculosis (TB). 

Drug resistance
Scientists assist the National Health Laboratory Service and Department of Health in trying to refine the diagnostic tools to identify these cases earlier. Dr Van der Spoel van Dijk explains: “Until recently, it took up to two years to fine-tune treatment decisions for patients with MDR-TB. Patients get a cocktail of anti-TB drugs, but it takes time to find the right combination. Re-infection and relapse (patients stopping treatment for several reasons) add to the diagnostic and treatment management challenges.

Enormous impact
“Now doctors can reduce the time needed for diagnostic certainty to about seven days, while new drugs allow reduction of treatment from more than 18 to nine months. This can have an enormous impact on the life of many patients.”

Dr Van der Spoel van Dijk’s work forms part of research in the faculty looking at resistance development in TB strains. She is currently also doing her doctoral thesis on the differences and incidence of MDR-TB among adolescents versus adults. Dr Van der Spoel van Dijk says: “It is a complicated picture, but we hope to unravel it to support better diagnostic tools and patient care.”

As part of the National Health Laboratory Service, her department is playing an important role in TB diagnostics and the training of scientists and future pathologists. “Our work is contributing to the global vision to stop TB by 2035,” Dr Van der Spoel van Dijk says.

News Archive

Professor triumphs at Water Research Commission (WRC) Symposium
2013-12-13

 
Prof Leon van Rensburg

The university’s advancement of research excellence recently found further embodiment in Prof Leon van Rensburg from the Department of Soil- and Crop- and Climate Sciences. His expertise in the water sector resulted in award-winning research.

Prof Van Rensburg received the award for Sustainable Development Solutions 2013 at the Water Research Commission (WRC) Symposium held at the CSIR in Pretoria. The symposium acknowledged local scientific solutions that have had a global impact. Prof Van Rensburg was recognised for his outstanding research guiding the management of salinity under irrigation at farm level in South Africa – ensuring food production. The paper that earned him this honour is entitled “Rainwater harvesting and conservation practices: challenges and opportunities for sustainable land and water use of ‘The Green Village’ in arid to semi-arid climate zones.”

The awards were linked to the WRC’s newly-adopted corporate planning tool named the ‘Knowledge Tree’, guiding the commission’s operations. The ‘Knowledge Tree’ functions as a yardstick with which the WRC measures its impact in essential areas. The presentation of these accolades underscored the importance of water science and water technology in improving the daily reality of people at grassroots level.

Prof Van Rensburg’s research goal is to enhance the efficiency of water usage of crop production systems in both the dryland and irrigation sectors. Part of his latest achievements include being editor for a special edition of the Irrigation and Drainage Journal (2012; vol 61) on rainwater harvesting.

Prof Chris du Preez, co-author of the winning paper, is an expert on soil quality, especially organic matter. He serves as the Head of the Department of Soil, Crop and Climate Sciences and has also acted as President of the Soil Science Society of South Africa. His current research focuses on agricultural land use and soil organic matter changes, soil fertility and fertilisation, and agriculture water quality and usage.

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