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07 January 2018 Photo Charl Devenish
Researcher tackling drug-resistant TB through molecular methods
Dr Anneke van der Spoel van Dijk is invested in contributing to the global effort of stopping TB by 2035.

The work of Dr Anneke van der Spoel van Dijk investigates the spread of TB in the Free State population using techniques such as next generation sequencing, spoligotyping and MIRU-VNTR typing. Dr Van der Spoel van Dijk, a senior medical scientist in the Department of Medical Microbiology at the University of the Free State (UFS) also looks at drug resistance in her research. This work informs decisions about how best to treat patients with multidrug-resistant TB (MDR-TB). 

She employs rapid molecular techniques to track one of Africa’s most serious diseases, tuberculosis (TB). 

Drug resistance
Scientists assist the National Health Laboratory Service and Department of Health in trying to refine the diagnostic tools to identify these cases earlier. Dr Van der Spoel van Dijk explains: “Until recently, it took up to two years to fine-tune treatment decisions for patients with MDR-TB. Patients get a cocktail of anti-TB drugs, but it takes time to find the right combination. Re-infection and relapse (patients stopping treatment for several reasons) add to the diagnostic and treatment management challenges.

Enormous impact
“Now doctors can reduce the time needed for diagnostic certainty to about seven days, while new drugs allow reduction of treatment from more than 18 to nine months. This can have an enormous impact on the life of many patients.”

Dr Van der Spoel van Dijk’s work forms part of research in the faculty looking at resistance development in TB strains. She is currently also doing her doctoral thesis on the differences and incidence of MDR-TB among adolescents versus adults. Dr Van der Spoel van Dijk says: “It is a complicated picture, but we hope to unravel it to support better diagnostic tools and patient care.”

As part of the National Health Laboratory Service, her department is playing an important role in TB diagnostics and the training of scientists and future pathologists. “Our work is contributing to the global vision to stop TB by 2035,” Dr Van der Spoel van Dijk says.

News Archive

Two degrees in three years for former teacher
2013-12-17

Jacqui Middleton

When Jacqui Middleton entered university in 2011, she did so alongside her daughter, both women enrolling for their first-year studies at the University of the Free State. Three years later and the mother of three have completed two degrees – a double feat achieved with distinction.

Middleton, a former teacher, will receive a BA degree in Corporate and Marketing Communications at the April 2014 graduation ceremony and a master’s degree in Sustainable Agriculture at the June graduation ceremony. With these two qualifications in the bag, Middleton will pursue her studies with a BCom Honours degree next year, as well as a PhD degree in Sustainable Agriculture.

“It was my first full-time studies since 1988,” says Middleton. “I was a teacher for 22 years and my husband kept saying that I needed to get out of the classroom and into the corporate world. I was reluctant because I was so passionate about education and my children were still at school.”

Things changed when Prof Jonathan Jansen, Vice-Chancellor and Rector of the UFS, visited the Ikanyegeng Primary and High School in Jacobsdal – where she was a teacher – to deliver a motivational talk. Middleton approached Prof Jansen about a bursary. The next year, with the support of her family, she moved to Bloemfontein and stayed on campus studying for two degrees.

“For me it was a major step of faith because we were relying on my salary and I had to give that up to study, so we had to believe there is something bigger beyond the three-year period.”

Something bigger definitely awaited. Her study record of the last three years reflects a dedicated student who passed most of her subjects with marks higher than 80%. 

With her new qualification, Middleton will follow a career in agriculture and farming with her husband. ”I am still passionate about education, but now I am passionate about educating farmers to assist with the land reform process. Land reform is crucial for food security in our country and at the moment we need more success stories of black farmers moving from emerging to commercial farming. I believe that whatever you studied in life should not be wasted.”

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